Microbiome and skin biology
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Accepted Version
Date
2019-08-01
Authors
Lunjani, Nonhlanhla
Hlela, Carol
O'Mahony, Liam
Journal Title
Journal ISSN
Volume Title
Publisher
Lippincott, Williams & Wilkins
Published Version
Abstract
Purpose of review: The skin is home to a diverse milieu of bacteria, fungi, viruses, bacteriophages, and archaeal communities. The application of culture-independent approaches has revolutionized the characterization of the skin microbiome and have revealed a previously underappreciated phylogenetic and functional granularity of skin-associated microbes in both health and disease states. Recent findings: The physiology of a given skin-niche drives the site-specific differences in bacterial phyla composition of healthy skin. Changes in the skin microbiome have consistently been associated with atopic dermatitis. In particular, Staphylococcus aureus overgrowth with concomitant decline in Staphylococcus epidermidis is a general feature associated with atopic dermatitis and is not restricted to eczematous lesions. Changes in fungal species are now also being described. Changes in the composition and metabolic activity of the gut microbiota are associated with skin health. Summary: We are now beginning to appreciate the intimate and intricate interactions between microbes and skin health. Multiple studies are currently focused on the manipulation of the skin or gut microbiome to explore their therapeutic potential in the prevention and treatment of skin inflammation.
Description
Keywords
Atopic dermatitis , Malassezia , Microbiome , Staphylococcus aureus
Citation
Lunjani, N., Hlela, C. and O'Mahony, L. (2019) 'Microbiome and skin biology', Current Opinion in Allergy and Clinical Immunology, 19(4), pp. 328-333. doi: 10.1097/aci.0000000000000542
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Copyright
© 2019, Wolters Kluwer Health, Inc. All rights reserved. This document is the Accepted Manuscript version of a Published Work that appeared in final form in Current Opinion in Allergy and Clinical Immunology. To access the final edited and published work see: https://doi.org/10.1097/aci.0000000000000542