Piezoelectric inkjet coating of injection moulded, reservoir-tipped microneedle arrays for transdermal delivery

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dc.contributor.author O'Mahony, Conor
dc.contributor.author Bocchino, Andrea
dc.contributor.author Haslinger, Michael J.
dc.contributor.author Brandstätter, Stefan
dc.contributor.author Außerhuber, Helene
dc.contributor.author Schossleitner, Klaudia
dc.contributor.author Clover, Anthony J. P.
dc.contributor.author Fechtig, Daniel
dc.date.accessioned 2019-08-27T15:35:21Z
dc.date.available 2019-08-27T15:35:21Z
dc.date.issued 2019-06-04
dc.identifier.citation O’Mahony, C., Bocchino, A., Haslinger, M. J., Brandstätter, S., Außerhuber, H., Schossleitner, K., Clover, A. J. P. and Fechtig, D. (2019) 'Piezoelectric inkjet coating of injection moulded, reservoir-tipped microneedle arrays for transdermal delivery', Journal of Micromechanics and Microengineering, 29 (8), 085004 (8 pp). doi: 10.1088/1361-6439/ab222b en
dc.identifier.volume 29 en
dc.identifier.issued 8 en
dc.identifier.startpage 1 en
dc.identifier.endpage 8 en
dc.identifier.issn 0960-1317
dc.identifier.uri http://hdl.handle.net/10468/8401
dc.identifier.doi 10.1088/1361-6439/ab222b en
dc.description.abstract Coated microneedles have significant potential for use in transdermal delivery applications. In this paper, we describe the fabrication of microneedle master templates using microstereolithography techniques and subsequently use a commercial injection moulding process to replicate these microneedles in biocompatible cyclic olefin polymer (COP) materials. Notably, the 475 μm-tall needle designs feature a shallow pit or reservoir at the tip, thereby providing both a target and holder for incoming droplets that are deposited using a piezoelectric inkjet printer. Using this design, no tilting or rotation of the needle array is required during the filling process. In the preliminary tests reported here, the reservoir is filled with a FITC-labelled dye that acts as a model drug, and ex vivo skin tests are used to verify skin penetration, the transfer of this model drug to the skin and to measure the reliability of the needles themselves. To our knowledge, this is the first time that such an inkjet-filled, reservoir-tipped microneedle has been demonstrated. en
dc.description.sponsorship Österreichische Forschungsförderungsgesellschaft (Austrian Research Promotion Agency (FFG) and was conducted in the framework of the program ‘Production of the future’ (MicroNeedle, Grant 853482)); Science Foundation Ireland (INSIGHT Centre, by Enterprise Ireland (CF/2012/2339)); Higher Education Authority (under the Programme for Research in Third-Level Institutions) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher IOP Publishing en
dc.relation.uri https://iopscience.iop.org/article/10.1088/1361-6439/ab222b/meta
dc.rights © 2019 IOP Publishing Ltd. This is an author-created, un-copyedited version of an article accepted for publication in Journal of Micromechanics and Microengineering. The publisher is not responsible for any errors or omissions in this version of the manuscript or any version derived from it. The Version of Record is available online at https://doi.org/10.1088/1361-6439/ab222b. en
dc.rights.uri https://creativecommons.org/licences/by-nc-nd/3.0 en
dc.subject Microneedles en
dc.subject Injection moulding en
dc.subject Piezoelectric inkjet dispensing en
dc.subject bioMEMS, en
dc.subject Transdermal drug delivery, en
dc.subject Microstereolithography en
dc.title Piezoelectric inkjet coating of injection moulded, reservoir-tipped microneedle arrays for transdermal delivery en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Conor O'Mahony, Tyndall Microsystems, University College Cork, Cork, Ireland. +353-21-490-3000 Email: conor.omahony@tyndall.ie en
dc.internal.availability Full text available en
dc.check.info Access to this article is restricted until 12 months after publication by request of the publisher. en
dc.check.date 2020-06-04
dc.date.updated 2019-08-27T15:24:08Z
dc.description.version Accepted Version en
dc.internal.rssid 495735240
dc.contributor.funder Österreichische Forschungsförderungsgesellschaft en
dc.contributor.funder Science Foundation Ireland en
dc.contributor.funder Higher Education Authority en
dc.contributor.funder Enterprise Ireland en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Journal of Micromechanics and Microengineering en
dc.internal.copyrightchecked No
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress conor.omahony@tyndall.ie en
dc.identifier.articleid 85004 en


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© 2019 IOP Publishing Ltd. This is an author-created, un-copyedited version of an article accepted for publication in Journal of Micromechanics and Microengineering. The publisher is not responsible for any errors or omissions in this version of the manuscript or any version derived from it. The Version of Record is available online at https://doi.org/10.1088/1361-6439/ab222b. Except where otherwise noted, this item's license is described as © 2019 IOP Publishing Ltd. This is an author-created, un-copyedited version of an article accepted for publication in Journal of Micromechanics and Microengineering. The publisher is not responsible for any errors or omissions in this version of the manuscript or any version derived from it. The Version of Record is available online at https://doi.org/10.1088/1361-6439/ab222b.
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