Timed degradation of Mcl-1 controls mitotic cell death

Clarke, Paul R.; Allan, Lindsey A.; Skowyra, Agnieszka

Timed degradation of Mcl-1 controls mitotic cell death

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Timed degradation of Mcl 1 controls mitotic cell death.pdf(2.05 MB)

Published version

Date

2018-10-11

Authors

Clarke, Paul R.

Allan, Lindsey A.

Skowyra, Agnieszka

Publisher

Taylor and Francis Ltd.

Published Version

10.1080/23723556.2018.1516450

Abstract

Mitotic arrest can result in cell death through the process of apoptosis. We have shown by live-cell imaging that the ubiquitin-proteasome dependent proteolysis of the apoptotic regulator Mcl-1 under the control of the anaphase-promoting complex or cyclosome (APC/C) provides a timing mechanism that distinguishes prolonged mitotic arrest from normal mitosis.

Keywords

Apoptosis , Mitosis , Mcl-1 , Mitotic cell death , Proteolysis

Citation

Clarke, P.R., Allan, L.A. and Skowyra, A., 2018. Timed degradation of Mcl-1 controls mitotic cell death. Molecular & cellular oncology, 5(6), (e1516450. DOI:10.1080/23723556.2018.1516450