Timed degradation of Mcl-1 controls mitotic cell death

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Timed degradation of Mcl-1 controls mitotic cell death

Clarke, Paul R.; Allan, Lindsey A.; Skowyra, Agnieszka
Date: 2018-10-11
Copyright: © 2018 The Author(s)
Copyright information: https://creativecommons.org/licenses/by-nc-nd/4.0/
Related: https://www.tandfonline.com/doi/full/10.1080/23723556.2018.1516450
Citation: Clarke, P.R., Allan, L.A. and Skowyra, A., 2018. Timed degradation of Mcl-1 controls mitotic cell death. Molecular & cellular oncology, 5(6), (e1516450. DOI:10.1080/23723556.2018.1516450
Published Version: 10.1080/23723556.2018.1516450

Abstract:

Mitotic arrest can result in cell death through the process of apoptosis. We have shown by live-cell imaging that the ubiquitin-proteasome dependent proteolysis of the apoptotic regulator Mcl-1 under the control of the anaphase-promoting complex or cyclosome (APC/C) provides a timing mechanism that distinguishes prolonged mitotic arrest from normal mitosis.

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© 2018 The Author(s) Except where otherwise noted, this item's license is described as © 2018 The Author(s)
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