Timed degradation of Mcl-1 controls mitotic cell death
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Published version
Date
2018-10-11
Authors
Clarke, Paul R.
Allan, Lindsey A.
Skowyra, Agnieszka
Journal Title
Journal ISSN
Volume Title
Publisher
Taylor and Francis Ltd.
Published Version
Abstract
Mitotic arrest can result in cell death through the process of apoptosis. We have shown by live-cell imaging that the ubiquitin-proteasome dependent proteolysis of the apoptotic regulator Mcl-1 under the control of the anaphase-promoting complex or cyclosome (APC/C) provides a timing mechanism that distinguishes prolonged mitotic arrest from normal mitosis.
Description
Keywords
Apoptosis , Mitosis , Mcl-1 , Mitotic cell death , Proteolysis
Citation
Clarke, P.R., Allan, L.A. and Skowyra, A., 2018. Timed degradation of Mcl-1 controls mitotic cell death. Molecular & cellular oncology, 5(6), (e1516450. DOI:10.1080/23723556.2018.1516450