Timed degradation of Mcl-1 controls mitotic cell death

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dc.contributor.author Clarke, Paul R.
dc.contributor.author Allan, Lindsey A.
dc.contributor.author Skowyra, Agnieszka
dc.date.accessioned 2019-09-02T14:35:14Z
dc.date.available 2019-09-02T14:35:14Z
dc.date.issued 2018-10-11
dc.identifier.citation Clarke, P.R., Allan, L.A. and Skowyra, A., 2018. Timed degradation of Mcl-1 controls mitotic cell death. Molecular & cellular oncology, 5(6), (e1516450. DOI:10.1080/23723556.2018.1516450 en
dc.identifier.volume 5 en
dc.identifier.issued 6 en
dc.identifier.startpage 1 en
dc.identifier.endpage 3 en
dc.identifier.uri http://hdl.handle.net/10468/8429
dc.identifier.doi 10.1080/23723556.2018.1516450 en
dc.description.abstract Mitotic arrest can result in cell death through the process of apoptosis. We have shown by live-cell imaging that the ubiquitin-proteasome dependent proteolysis of the apoptotic regulator Mcl-1 under the control of the anaphase-promoting complex or cyclosome (APC/C) provides a timing mechanism that distinguishes prolonged mitotic arrest from normal mitosis. en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Taylor and Francis Ltd. en
dc.relation.uri https://www.tandfonline.com/doi/full/10.1080/23723556.2018.1516450
dc.rights © 2018 The Author(s) en
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/ en
dc.subject Apoptosis en
dc.subject Mitosis en
dc.subject Mcl-1 en
dc.subject Mitotic cell death en
dc.subject Proteolysis en
dc.title Timed degradation of Mcl-1 controls mitotic cell death en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Agnieszka Skowyra, APC Microbiome Ireland, University College Cork, Cork, Ireland. +353-21-490-3000 Email: agnieszka.skowyra@ucc.ie en
dc.internal.availability Full text available en
dc.description.version Published Version en
dc.contributor.funder Cancer Research UK en
dc.contributor.funder Association for International Cancer Research en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Molecular and Cellular Oncology en
dc.internal.IRISemailaddress agnieszka.skowyra@ucc.ie en
dc.identifier.articleid e1516450 en
dc.identifier.eissn 2372-3556


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