Biodiversity and classification of phages infecting Lactobacillus brevis

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dc.contributor.author Feyereisen, Marine
dc.contributor.author Mahony, Jennifer
dc.contributor.author Neve, Horst
dc.contributor.author Franz, Charles M. A. P.
dc.contributor.author Noben, Jean-Paul
dc.contributor.author O'Sullivan, Tadhg
dc.contributor.author Boer, Viktor
dc.contributor.author van Sinderen, Douwe
dc.date.accessioned 2019-10-23T04:48:38Z
dc.date.available 2019-10-23T04:48:38Z
dc.date.issued 2019-10-16
dc.identifier.citation Feyereisen, M., Mahony, J., Neve, H., Franz, C. M. A. P., Noben, J.-P., O’Sullivan, T., Boer, V. and van Sinderen, D. (2019) 'Biodiversity and Classification of Phages Infecting Lactobacillus brevis', Frontiers in Microbiology, 10, 2396. (12pp.) DOI: 10.3389/fmicb.2019.02396 en
dc.identifier.volume 10 en
dc.identifier.startpage 1 en
dc.identifier.endpage 12 en
dc.identifier.uri http://hdl.handle.net/10468/8836
dc.identifier.doi 10.3389/fmicb.2019.02396 en
dc.description.abstract Lactobacillus brevis is a lactic acid bacterium that is known as a food and beverage spoilage organism, and more specifically as a beer-spoiler. Phages of L. brevis have been described, but very limited data is available regarding temperate phages of L. brevis. Temperate phages may exert benefits to the host, while they may also be employed to combat beer spoilage. The current study reports on the incidence of prophage sequences present in nineteen distinct L. brevis genomes. Prophage induction was evaluated using mitomycin C exposure followed by genome targeted-PCR, electron microscopy and structural proteome analysis. The morphological and genome sequence analyses revealed significant diversity among L. brevis prophages, which appear to be dominated by members of the Myoviridae phage family. Based on this analysis, we propose a classification of L. brevis phages into five groups. en
dc.description.sponsorship Irish Research Council (Enterprise Partnership Scheme postgraduate scholarship (Ref. No. EPSPG/2015/7)) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Frontiers Media en
dc.relation.uri https://www.frontiersin.org/articles/10.3389/fmicb.2019.02396/full
dc.rights © 2019 Feyereisen, Mahony, Neve, Franz, Noben, O’Sullivan, Boer and van Sinderen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. en
dc.rights.uri http://creativecommons.org/licenses/by/4.0/ en
dc.subject Lactic acid bacteria en
dc.subject Beer spoilage en
dc.subject Bacteriophage en
dc.subject Lysogeny en
dc.subject Prophage en
dc.subject Genomic analysis en
dc.subject Induction en
dc.subject Myoviridae en
dc.title Biodiversity and classification of phages infecting Lactobacillus brevis en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Marine Feyeresisen, School of Microbiology, University College Cork, Cork, Ireland. +353-21-490-3000 Email:116221209@umail.ucc.ie en
dc.internal.availability Full text available en
dc.description.version Published Version en
dc.contributor.funder Irish Research Council en
dc.contributor.funder Science Foundation Ireland en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Frontiers in Microbiology en
dc.internal.IRISemailaddress 116221209@umail.ucc.ie en
dc.identifier.articleid 2396 en
dc.relation.project info:eu-repo/grantAgreement/SFI/SFI Investigator Programme/13/IA/1953/IE/Functional analysis of the host adsorption and DNA injection processes of a lactococcal bacteriophage/ en
dc.relation.project info:eu-repo/grantAgreement/SFI/SFI Starting Investigator Research Grant (SIRG)/15/SIRG/3430/IE/Phage-host interactome of the dairy bacterium Streptococcus thermophilus (PHIST)/ en
dc.identifier.eissn 1664-302X


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© 2019 Feyereisen, Mahony, Neve, Franz, Noben, O’Sullivan, Boer and van Sinderen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. Except where otherwise noted, this item's license is described as © 2019 Feyereisen, Mahony, Neve, Franz, Noben, O’Sullivan, Boer and van Sinderen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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