Characterization and modeling of acousto-optic signal strengths in highly scattering media

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dc.contributor.author Bengtsson, Alexander
dc.contributor.author Hill, David
dc.contributor.author Li, Meng
dc.contributor.author Di, Mengqiao
dc.contributor.author Cinthio, Magnus
dc.contributor.author Erlöv, Tobias
dc.contributor.author Andersson-Engels, Stefan
dc.contributor.author Reistad, Nina
dc.contributor.author Walther, Andreas
dc.contributor.author Rippe, Lars
dc.contributor.author Kröll, Stefan
dc.date.accessioned 2019-10-26T06:35:50Z
dc.date.available 2019-10-26T06:35:50Z
dc.date.issued 2019-09-07
dc.identifier.citation Bengtsson, A., Hill, D., Li, M., Di, M., Cinthio, M., Erlöv, T., Andersson-Engels, S., Reistad, N., Walther, A., Rippe, L. and Kröll, S. (2019) 'Characterization and modeling of acousto-optic signal strengths in highly scattering media', Biomedical Optics Express, 10(11), 371226, pp. 5565-5584. DOI: 10.1364/BOE.10.005565 en
dc.identifier.volume 10 en
dc.identifier.issued 11 en
dc.identifier.startpage 5565 en
dc.identifier.endpage 5584 en
dc.identifier.uri http://hdl.handle.net/10468/8869
dc.identifier.doi 10.1364/BOE.10.005565 en
dc.description.abstract Ultrasound optical tomography (UOT) is an imaging technique based on the acousto-optic effect that can perform optical imaging with ultrasound resolution inside turbid media, and is thus interesting for biomedical applications, e.g. for assessing tissue blood oxygenation. In this paper, we present near background free measurements of UOT signal strengths using slow light filter signal detection. We carefully analyze each part of our experimental setup and match measured signal strengths with calculations based on diffusion theory. This agreement between experiment and theory allows us to assert the deep tissue imaging potential of ∼5 cm for UOT of real human tissues predicted by previous theoretical studies [Biomed. Opt. Express 8, 4523 (2017)] with greater confidence, and indicate that future theoretical analysis of optimized UOT systems can be expected to be reliable. en
dc.description.sponsorship Knut and Alice Wallenberg Foundation (KAW 2016.0081, KAW 2017.0449 and Wallenberg Center for Quantum Technology (WACQT) No. 2017.0449) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Optical Society of America en
dc.relation.uri https://www.osapublishing.org/boe/fulltext.cfm?uri=boe-10-11-5565&id=422082
dc.rights ©2019 Optical Society of America under the terms of the OSA Open Access Publishing Agreement en
dc.rights.uri https://doi.org/10.1364/OA_License_v1 en
dc.subject Inhomogeneously broadened lasers en
dc.subject Medical imaging en
dc.subject Optical pumping en
dc.subject Real time imaging en
dc.subject Slow light en
dc.subject Tissue imaging en
dc.title Characterization and modeling of acousto-optic signal strengths in highly scattering media en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Stefan Andersson-Engels, Department of Physics and Tyndall National Institute, University College Cork, Cork, Ireland. +353-21-490-3000 Email:stefan.andersson-engels@tyndall.ie en
dc.internal.availability Full text available en
dc.description.version Published Version en
dc.contributor.funder Knut och Alice Wallenbergs Stiftelse en
dc.contributor.funder Lunds Tekniska Högskola, Lunds universitet en
dc.contributor.funder Science Foundation Ireland en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Biomedical Optics Express en
dc.internal.IRISemailaddress stefan.andersson-engels@tyndall.ie en
dc.identifier.articleid 371226 en
dc.relation.project info:eu-repo/grantAgreement/SFI/SFI Research Professorship Programme/15/RP/2828/IE/Novel applications and techniques for in vivo optical imaging and spectroscopy/ en
dc.identifier.eissn 2156-7085


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