Bifidobacterium bifidum PRL2010 alleviates intestinal ischemia/reperfusion injury

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dc.contributor.author Duranti, Sabrina
dc.contributor.author Vivo, Valentina
dc.contributor.author Zini, Irene
dc.contributor.author Milani, Christian
dc.contributor.author Mangifesta, Marta
dc.contributor.author Anzalone, Rosaria
dc.contributor.author Mancabelli, Leonardo
dc.contributor.author Viappiani, Alice
dc.contributor.author Cantoni, Anna Maria
dc.contributor.author Barocelli, Elisabetta
dc.contributor.author van Sinderen, Douwe
dc.contributor.author Bertoni, Simona
dc.contributor.author Turroni, Francesca
dc.date.accessioned 2019-10-28T07:05:07Z
dc.date.available 2019-10-28T07:05:07Z
dc.date.issued 2018-08-30
dc.identifier.citation Duranti, S., Vivo, V., Zini, I., Milani, C., Mangifesta, M., Anzalone, R., Mancabelli, L., Viappiani, A., Cantoni, A.M., Barocelli, E. and van Sinderen, D., 2018. Bifidobacterium bifidum PRL2010 alleviates intestinal ischemia/reperfusion injury. PloS one, 13(8), e0202670, (16 pp.). DOI:10.1371/journal.pone.0202670 en
dc.identifier.volume 13 en
dc.identifier.issued 8 en
dc.identifier.startpage 1 en
dc.identifier.endpage 16 en
dc.identifier.uri http://hdl.handle.net/10468/8890
dc.identifier.doi 10.1371/journal.pone.0202670 en
dc.description.abstract Mesenteric ischemia/reperfusion is a clinical emergency with high morbidity and mortality due to the transient reduction of blood supply to the bowel. In recent years, the critical contribution of gut microbiome to human health and proper gastrointestinal functions has gradually emerged. In the current study, we investigated the protective effects of five days supplementation with Bifidobacterium bifidum PRL2010 in a murine model of gut ischemia/reperfusion. Our findings indicate that animals pretreated with B. bifidum PRL2010 showed lower neutrophil recruitment in the lungs, remarkably reduced bacterial translocation and decreased transcription levels of TNFalpha and IL-10 both in liver and kidneys, at the same time increasing those of IL-12 in kidneys. Inhibiting the adhesion of pathogenic bacteria and boosting host innate immunity responses are among the possible protective mechanisms enacted by the probiotic. These results demonstrate that short-period treatment with B. bifidum PRL2010 is a potential strategy to dampen remote organ injury due to mesenteric ischemia/reperfusion. en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher PLoS en
dc.relation.uri https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0202670
dc.rights © 2018 Duranti et al. GenProbio This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. en
dc.rights.uri https://creativecommons.org/licenses/by/4.0/ en
dc.subject Intestinal ischemia/reperfusion injury en
dc.subject Gut microbiome en
dc.subject Bifidobacterium bifidum PRL2010 en
dc.subject Human health en
dc.title Bifidobacterium bifidum PRL2010 alleviates intestinal ischemia/reperfusion injury en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Douwe van Sinderen, School of Microbiology, University College Cork, Cork, Ireland. +353-21-490-3000 Email: d.vansinderen@ucc.ie en
dc.internal.availability Full text available en
dc.description.version Published Version en
dc.contributor.funder Science Foundation Ireland en
dc.contributor.funder GenProbio srl en
dc.description.status Peer reviewed en
dc.identifier.journaltitle PLoS ONE en
dc.internal.IRISemailaddress d.vansinderen@ucc.ie en
dc.identifier.articleid e0202670 en
dc.relation.project info:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/ en
dc.identifier.eissn 1932-6203


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© 2018 Duranti et al. GenProbio This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Except where otherwise noted, this item's license is described as © 2018 Duranti et al. GenProbio This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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