Exposure of children to rural lifestyle factors associated with protection against allergies induces an anti-Neu5Gc antibody response

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Date
2019-07-16
Authors
Frei, Remo
Roduit, Caroline
Ferstl, Ruth
O'Mahony, Liam
Lauener, Roger P.
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Publisher
Frontiers Media
Published Version
10.3389/fimmu.2019.01628
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Abstract
Rural lifestyle has been shown to be highly protective against the development of allergies. Contact to farm-animals or pets and early-life consumption of milk products that turned out to be important. These exposures provide contact to N-glycolylneuraminic acid (Neu5Gc), a sialic acid naturally expressed in mammalians but not in humans or microbes although both are able to incorporate exogenously provided Neu5Gc and induce thereby and anti-Neu5Gc antibody response. Farmers’ children had elevated levels of anti-Neu5Gc antibodies associated with increased contact to Neu5Gc. Farm-related exposures that were associated with protection against allergies such as exposure to farm-animals or pets and consumption of milk were also associated with an antibody response to Neu5Gc in children. Exposure to cats was associated with increased anit-Neu5Gc IgG levels at different timepoints assessed between one year of age and school-age. Moreover, consumption of non-pasteurized milk in the first year of life was associated with increased anti-Neu5Gc IgG levels. Neu5Gc-providing exposures that were associated with protection against allergies were reflected in an elevated anti-Neu5Gc IgG level in children. Exposure to Neu5Gc was associated with anti-inflammation and protection of asthma development in children and mice without contribution of anti-Neu5Gc antibodies.
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Keywords
N-glycolyl neuraminic acid , Asmtha , Regulatory T (Treg) cell , Anti-inflammation , Animal contact , Hygiene hypothesis
Citation
Frei, R., Roduit, C., Ferstl, R., O'Mahony, L. and Lauener, R. (2019) 'Exposure of children to rural lifestyle factors associated with protection against allergies induces an anti-Neu5Gc antibody response', Frontiers in Immunology, 10, 1628 (5pp). doi:10.3389/fimmu.2019.01628
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https://hdl.handle.net/10468/8958
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Medicine - Journal Articles
APC Microbiome Ireland - Journal Articles
Microbiology - Journal Articles
Copyright
© 2019 Frei, Roduit, Ferstl, O'Mahony and Lauener. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.