Explicit criteria as clinical tools to minimize inappropriate medication use and its consequences

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dc.contributor.author Curtin, Denis
dc.contributor.author Gallagher, Paul F.
dc.contributor.author O'Mahony, Denis
dc.date.accessioned 2019-11-20T06:08:39Z
dc.date.available 2019-11-20T06:08:39Z
dc.date.issued 2019-02-13
dc.identifier.citation Curtin, D., Gallagher, P.F. and O’Mahony, D., 2019. Explicit criteria as clinical tools to minimize inappropriate medication use and its consequences. Therapeutic advances in drug safety, 10, (2042098619829431). DOI: 10.1177/2042098619829431 en
dc.identifier.volume 10 en
dc.identifier.startpage 1 en
dc.identifier.endpage 10 en
dc.identifier.issn 2042-0986
dc.identifier.uri http://hdl.handle.net/10468/9161
dc.identifier.doi 10.1177/2042098619829431 en
dc.description.abstract Polypharmacy and prescribing of potentially inappropriate medications (PIMs) are the key elements of inappropriate medication use (IMU) in older multimorbid people. IMU is associated with a range of negative healthcare consequences including adverse drug events and unplanned hospitalizations. Furthermore, prescribing guidelines are commonly derived from randomized controlled clinical trials which have specifically excluded older adults with multimorbidity. Consequently, indiscriminate application of single disease pharmacotherapy guidelines to older multimorbid patients can lead to increased risk of drug?drug interactions, drug?disease interactions and poor drug adherence. Both polypharmacy and PIMs are highly prevalent in older people and strategies to improve the quality and safety of prescribing, largely through avoidance of IMU, are needed. In the last 30?years, numerous explicit PIM criteria-based tools have been developed to assist physicians with medication management in clinically complex multimorbid older people. Very few of these PIM criteria sets have been tested as an intervention compared with standard pharmaceutical care in well-designed clinical trials. In this review, we describe the most widely used sets of explicit PIM criteria to address inappropriate polypharmacy with particular focus on STOPP/START criteria and FORTA criteria which have been associated with positive patient-related outcomes when used as interventions in recent randomized controlled trials. en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher SAGE Journals en
dc.relation.uri https://journals.sagepub.com/doi/10.1177/2042098619829431
dc.rights © The Author(s), 2019. Article reuse guidelines: sagepub.com/journalspermissions en
dc.rights.uri http://creativecommons.org/licenses/by-nc/4.0/ en
dc.subject Inappropriate prescribing en
dc.subject Explicit criteria en
dc.subject Elderly en
dc.subject Multimorbidity en
dc.subject Polypharmacy en
dc.subject Adverse drug reaction en
dc.subject Adverse drug event en
dc.title Explicit criteria as clinical tools to minimize inappropriate medication use and its consequences en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Denis O'Mahony, Depatment of Medicine, University College Cork, Cork, Ireland. +353-21-490-3000 Email: denis.omahony@ucc.ie en
dc.internal.availability Full text available en
dc.description.version Published Version en
dc.contributor.funder Seventh Framework Programme en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Therapeutic Advances in Drug Safety en
dc.internal.IRISemailaddress denis.omahony@ucc.ie en
dc.identifier.articleid 2042098619829431 en
dc.relation.project info:eu-repo/grantAgreement/EC/FP7::SP1::HEALTH/305930/EU/Development and clinical trials of a new Software ENgine for the Assessment & Optimization of drug and non-drug Therapy in Older peRsons/SENATOR en
dc.identifier.eissn 2042-0994


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© The Author(s), 2019. Article reuse guidelines: sagepub.com/journalspermissions Except where otherwise noted, this item's license is described as © The Author(s), 2019. Article reuse guidelines: sagepub.com/journalspermissions
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