Quantification of human milk phospholipids: The effect of gestational and lactational age on phospholipid composition

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dc.contributor.author Ingvordsen Lindahl, Ida Emilie
dc.contributor.author Artegoitia, Virginia M.
dc.contributor.author Downey, Eimear
dc.contributor.author O'Mahony, James A.
dc.contributor.author O'Shea, Carol Anne
dc.contributor.author Ryan, C. Anthony
dc.contributor.author Kelly, Alan L.
dc.contributor.author Bertram, Hanne C.
dc.contributor.author Sundekilde, Ulrik K.
dc.date.accessioned 2019-11-20T06:10:38Z
dc.date.available 2019-11-20T06:10:38Z
dc.date.issued 2019-01-22
dc.identifier.citation Lindahl, I., Emilie, I., Artegoitia, V.M., Downey, E., O’Mahony, J.A., O’Shea, C.A., Ryan, C.A., Kelly, A.L., Bertram, H.C. and Sundekilde, U.K., 2019. Quantification of Human Milk Phospholipids: The Effect of Gestational and Lactational Age on Phospholipid Composition. Nutrients, 11(2), (222). DOI:10.3390/nu11020222 en
dc.identifier.volume 11 en
dc.identifier.issued 2 en
dc.identifier.startpage 1 en
dc.identifier.endpage 14 en
dc.identifier.issn 2072-6643
dc.identifier.uri http://hdl.handle.net/10468/9164
dc.identifier.doi 10.3390/nu11020222 en
dc.description.abstract Human milk (HM) provides infants with macro- and micronutrients needed for growth and development. Milk phospholipids are important sources of bioactive components, such as long-chain polyunsaturated fatty acids (LC-PUFA) and choline, crucial for neural and visual development. Milk from mothers who have delivered prematurely (<37 weeks) might not meet the nutritional requirements for optimal development and growth. Using liquid chromatography tandem-mass spectrometry, 31 phospholipid (PL) species were quantified for colostrum (<5 days postpartum), transitional (≥5 days and ≤2 weeks) and mature milk (>2 weeks and ≤15 weeks) samples from mothers who had delivered preterm (n = 57) and term infants (n = 22), respectively. Both gestational age and age postpartum affected the PL composition of HM. Significantly higher concentrations (p < 0.05) of phosphatidylcholine (PC), sphingomyelin (SM) and total PL were found in preterm milk throughout lactation, as well as significantly higher concentrations (p < 0.002) of several phosphatidylethanolamine (PE), PC and SM species. Multivariate analysis revealed that PLs containing LC-PUFA contributed highly to the differences in the PL composition of preterm and term colostrum. Differences related to gestation decreased as the milk matured. Thus, gestational age may impact the PL content of colostrum, however this effect of gestation might subside in mature milk. en
dc.description.sponsorship Grant 2017-524 en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher MDPI en
dc.relation.uri https://www.mdpi.com/2072-6643/11/2/222
dc.rights © 2019 by the authors. Licensee MDPI, Basel, Switzerland en
dc.rights.uri https://creativecommons.org/licenses/by/4.0/ en
dc.subject Human milk en
dc.subject Preterm infant en
dc.subject Phospholipids en
dc.subject Lipidomics en
dc.subject Milk fat globule membrane en
dc.title Quantification of human milk phospholipids: The effect of gestational and lactational age on phospholipid composition en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Seamus Anthony O'Mahony, School of Food and Nutritional Sciences, University College Cork, Cork, Ireland. +353-21-490-3000 Email: sa.omahony@ucc.ie en
dc.internal.availability Full text available en
dc.description.version Published Version en
dc.contributor.funder Aarhus Universitet en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Nutrients en
dc.internal.IRISemailaddress sa.omahony@ucc.ie en
dc.identifier.articleid 222 en
dc.identifier.eissn 2072-6643

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© 2019 by the authors. Licensee MDPI, Basel, Switzerland Except where otherwise noted, this item's license is described as © 2019 by the authors. Licensee MDPI, Basel, Switzerland
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