Human skin microbiota is a rich source of bacteriocin-producing staphylococci that kill human pathogens

Show simple item record

dc.contributor.author O'Sullivan, Julie N.
dc.contributor.author Rea, Mary C.
dc.contributor.author O'Connor, Paula M.
dc.contributor.author Hill, Colin
dc.contributor.author Ross, R. Paul
dc.date.accessioned 2019-11-26T05:50:47Z
dc.date.available 2019-11-26T05:50:47Z
dc.date.issued 2018-12-24
dc.identifier.citation O'Sullivan, J.N., Rea, M.C., O'Connor, P.M., Hill, C. and Ross, R.P. (2018) 'Human skin microbiota is a rich source of bacteriocin-producing staphylococci that kill human pathogens'. FEMS microbiology ecology, 95(2), fiy241. (10pp). doi:10.1093/femsec/fiy241 en
dc.identifier.volume 95 en
dc.identifier.issued 2 en
dc.identifier.startpage 1 en
dc.identifier.endpage 10 en
dc.identifier.issn 0168-6496
dc.identifier.uri http://hdl.handle.net/10468/9228
dc.identifier.doi 10.1093/femsec/fiy241 en
dc.description.abstract The demand for novel antimicrobial therapies due to the threat posed by antimicrobial resistance has resulted in a growing interest in the protective role of our skin bacteria and the importance of competition among bacteria on the skin. A survey of the cultivable bacteria on human skin was undertaken to identify the capacity of the skin microbiota to produce bacteriocins with activity against skin pathogens. Twenty-one bacteriocins produced by bacteria isolated from seven sites on the human body of each subject exhibited inhibition spectra ranging from broad to narrow range, inhibiting many Gram-positive bacteria, including opportunistic skin pathogens such as Propionibacterium acnes (recently renamed Cutibacterium acnes), Staphylococcus epidermidis and methicillin-resistant Staphylococcus aureus (MRSA). Sequencing indicated that the antimicrobial-producing isolates were predominately species/strains of the Staphylococcus genus. Colony mass spectrometry revealed peptide masses that do not correspond to known bacteriocins. In an era where antibiotic resistance is of major concern, the inhibitory effect of novel bacteriocins from the bacteria of skin origin demonstrates the antimicrobial potential that could be harnessed from within the human skin microbiota. en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher FEMS en
dc.relation.uri https://academic.oup.com/femsec/article/95/2/fiy241/5259109
dc.rights © 2019 Oxford University Press. © FEMS 2018. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com en
dc.rights.uri http://creativecommons.org/licenses/by-nc/4.0/ en
dc.subject Skin pathogens en
dc.subject Staphylococci en
dc.subject Antimicrobial potential en
dc.subject Bacteriocin en
dc.subject Skin microbiota en
dc.subject Skin microbiome en
dc.title Human skin microbiota is a rich source of bacteriocin-producing staphylococci that kill human pathogens en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Colin Hill, School of Microbiology, University College Cork, Cork, Ireland. +353-21-490-3000 Email: c.hill@ucc.ie en
dc.internal.availability Full text available en
dc.description.version Published Version en
dc.contributor.funder Science Foundation Ireland en
dc.description.status Peer reviewed en
dc.identifier.journaltitle FEMS Microbiology Ecology en
dc.internal.IRISemailaddress c.hill@ucc.ie en
dc.identifier.articleid fiy241 en
dc.relation.project info:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/ en
dc.identifier.eissn 1574-6941


Files in this item

This item appears in the following Collection(s)

Show simple item record

© 2019 Oxford University Press. © FEMS 2018. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com Except where otherwise noted, this item's license is described as © 2019 Oxford University Press. © FEMS 2018. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
This website uses cookies. By using this website, you consent to the use of cookies in accordance with the UCC Privacy and Cookies Statement. For more information about cookies and how you can disable them, visit our Privacy and Cookies statement