May the force be with you: The light and dark sides of the microbiota–gut–brain axis in neuropsychiatry
Loading...
Files
Published version
Date
2016-07-14
Authors
Sherwin, Eoin
Sandhu, Kiran V.
Dinan, Timothy G.
Cryan, John F.
Journal Title
Journal ISSN
Volume Title
Publisher
Springer International Publishing
Published Version
Abstract
The role of the gut microbiota in health and disease is becoming increasingly recognized. The microbiota–gut–brain axis is a bi-directional pathway between the brain and the gastrointestinal system. The bacterial commensals in our gut can signal to the brain through a variety of mechanisms, which are slowly being resolved. These include the vagus nerve, immune mediators and microbial metabolites, which influence central processes such as neurotransmission and behaviour. Dysregulation in the composition of the gut microbiota has been identified in several neuropsychiatric disorders, such as autism, schizophrenia and depression. Moreover, preclinical studies suggest that they may be the driving force behind the behavioural abnormalities observed in these conditions. Understanding how bacterial commensals are involved in regulating brain function may lead to novel strategies for development of microbiota-based therapies for these neuropsychiatric disorders.
Description
Keywords
Autism spectrum disorder , Lactobacillus , Irritable bowel syndrome , Vagus nerve , Kynurenine
Citation
Sherwin, E., Sandhu, K. V., Dinan, T. G. and Cryan, J. F. (2016) 'May the Force Be With You: The Light and Dark Sides of the Microbiota–Gut–Brain Axis in Neuropsychiatry', CNS Drugs, 30(11), pp. 1019-1041. doi: 10.1007/s40263-016-0370-3