The relationship between fish intake and urinary trimethylamine-N-oxide.

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dc.contributor.author Yin, Xiaofei
dc.contributor.author Gibbons, Helena
dc.contributor.author Rundle, Milena
dc.contributor.author Frost, Gary
dc.contributor.author McNulty, Breige A.
dc.contributor.author Nugent, Anne P.
dc.contributor.author Walton, Janette
dc.contributor.author Flynn, Albert
dc.contributor.author Brennan, Lorraine
dc.date.accessioned 2020-02-27T16:03:09Z
dc.date.available 2020-02-27T16:03:09Z
dc.date.issued 2019-12-21
dc.identifier.citation Yin, X., Gibbons, H., Rundle, M., Frost, G., McNulty, B. A., Nugent, A. P., Walton, J., Flynn, A. and Brennan, L. (2020) 'The Relationship between Fish Intake and Urinary Trimethylamine-N-Oxide', Molecular Nutrition & Food Research, 64(3), 1900799 (9 pp). doi: 10.1002/mnfr.201900799 en
dc.identifier.volume 64 en
dc.identifier.issued 3 en
dc.identifier.startpage 1 en
dc.identifier.endpage 9 en
dc.identifier.issn 1613-4125
dc.identifier.uri http://hdl.handle.net/10468/9710
dc.identifier.doi 10.1002/mnfr.201900799 en
dc.description.abstract Scope: Fish intake is reported to be associated with certain health benefits; however, accurate assessment of fish intake is still problematic. The objective of this study is to identify fish intake biomarkers and examine relationships with health parameters in a free‐living population. Methods and results: In the NutriTech study, ten participants randomized into the fish group consume increasing quantities of fish for 3 days per week for 3 weeks. Urine is analyzed by NMR spectroscopy. Trimethylamine‐N‐oxide (TMAO), dimethylamine, and dimethyl sulfone are identified and display significant dose–response with intake (p < 0.05). Fish consumption yields a greater increase in urinary TMAO compared to red meat. Biomarker‐derived fish intake is calculated in the National Adult Nutrition Survey cross‐sectional study. However, the correlation between fish intake and TMAO (r = 0.148, p < 0.01) and that between fish intake and calculated fish intake (r = 0.142, p < 0.01) are poor. In addition, TMAO shows significantly positive correlation with serum insulin and insulin resistance in males and the relationship is more pronounced for males with high dietary fat intake. Conclusion: Urinary TMAO displays a strong dose–response relationship with fish intake; however, use of TMAO alone is insufficient to determine fish intake in a free‐living population. en
dc.description.sponsorship Department of Agriculture, Fisheries, and Food, Ireland (under the Food for Health Research Initiative (2007–2012; 7FHRIUCC2) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Wiley en
dc.relation.uri https://onlinelibrary.wiley.com/doi/full/10.1002/mnfr.201900799
dc.rights © 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. This is the peer reviewed version of the following article: ‘The Relationship between Fish Intake and Urinary Trimethylamine‐N‐Oxide’, Mol. Nutr. Food Res. 2020, 64, 1900799.which has been published in final form at https://doi.org/10.1002/mnfr.201900799. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. en
dc.subject Dietary biomarkers en
dc.subject Fish intake en
dc.subject Metabolomics en
dc.subject trimethylamine‐N‐oxide en
dc.title The relationship between fish intake and urinary trimethylamine-N-oxide. en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Janette Walton, Food and Nutritional Sciences, University College Cork, Cork, Ireland. +353-21-490-3000 Email: janette.walton@ucc.ie en
dc.internal.availability Full text available en
dc.check.info Access to this article is restricted until 12 months after publication by request of the publisher. en
dc.check.date 2020-12-21
dc.date.updated 2020-02-27T15:52:04Z
dc.description.version Accepted Version en
dc.internal.rssid 500172016
dc.contributor.funder Seventh Framework Programme en
dc.contributor.funder European Research Council en
dc.contributor.funder Horizon 2020 en
dc.contributor.funder Department of Agriculture, Food and the Marine en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Molecular Nutrition & Food Research en
dc.internal.copyrightchecked Yes
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress a.flynn@ucc.ie en
dc.internal.IRISemailaddress janette.walton@ucc.ie en
dc.identifier.articleid 1900799 en
dc.relation.project info:eu-repo/grantAgreement/EC/FP7::SP1::KBBE/289511/EU/Application of new technologies and methods in nutrition research – the example of phenotypic flexibility/NUTRITECH en
dc.relation.project info:eu-repo/grantAgreement/EC/H2020::ERC::ERC-COG/647783/EU/Metabolomics based biomarkers of dietary intake- new tools for nutrition research/A-DIET en


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