Nanosize and shape effects on antimicrobial activity of silver using morphology-controlled nanopatterns by block copolymer fabrication

Show simple item record Ghoshal, Tandra Cruz-Romero, Malco C. Kerry, Joseph P. Morris, Michael A. 2020-03-31T16:08:17Z 2020-03-31T16:08:17Z 2019-10-04
dc.identifier.citation Ghoshal, T., Cruz-Romero, M. C., Kerry, J. P., Morris, M. A. (2019) 'Nanosize and Shape Effects on Antimicrobial Activity of Silver Using Morphology-Controlled Nanopatterns by Block Copolymer Fabrication', ACS Applied Nano Materials, 2 (10), pp. 6325-6333. doi: 10.1021/acsanm.9b01286 en
dc.identifier.volume 2 en
dc.identifier.issued 10 en
dc.identifier.startpage 6325 en
dc.identifier.endpage 6333 en
dc.identifier.issn 2574-0970
dc.identifier.doi 10.1021/acsanm.9b01286 en
dc.description.abstract The activity of silver nanomaterials as an antimicrobial is well-known with authors noting strong size and shape effects. This paper explores if the antimicrobial activity relates to unique size-related properties of the nanodimensioned materials or a more physical effect. Staphylococcus aureus and Pseudomonas aeruginosa were explored as test bacteria. They can cause serious human infections and are becoming resistant to pharmaceutical antimicrobials. Silver nanopatterns on a substrate surface were used as the antimicrobial agent. We demonstrate a cost-effective facile route to fabricate a well-ordered, periodic, and dimension-controlled silver lines and dots pattern on a substrate surface. This allowed precise definition of the silver materials to explore size and shape effects. Polystyrene-b-poly(ethylene oxide) (PS-b-PEO) block copolymer (BCP) microphase separated thin films were used as structural templates. Well-ordered PS-b-PEO thin film with vertical and parallel oriented PEO cylinders was achieved by a solvent vapor annealing approach through careful optimization of experimental parameters. A selective inclusion method (into one block of the BCP) of silver nitrate was used to generate the silver nanopatterns. Spin coating precursor-ethanol solution and subsequent UV/ozone treatment produce silver nanopattern arrays. They exhibited a significant growth-inhibitory effect on Staphylococcus aureus and Pseudomonas aeruginosa biofilms. However, data suggest this is associated with high surface area rather than a unique nanodimension related property change dictated by size or shape. en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher American Chemical Society en
dc.rights © 2019 American Chemical Society. This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Applied Nano Materials, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see en
dc.subject Antimicrobial en
dc.subject Block copolymer en
dc.subject Nanopatterns en
dc.subject Optical en
dc.subject Self-assembly en
dc.subject Silver en
dc.subject Substrate en
dc.subject Surface area en
dc.title Nanosize and shape effects on antimicrobial activity of silver using morphology-controlled nanopatterns by block copolymer fabrication en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Joseph Kerry, Dept Of Food & Nutritional Sciences, University College Cork, Cork, Ireland. +353-21-490-3000 Email: en
dc.internal.availability Full text available en Access to this article is restricted until 12 months after publication by request of the publisher. en 2020-10-04 2020-03-31T15:49:43Z
dc.description.version Accepted Version en
dc.internal.rssid 500166380
dc.contributor.funder Science Foundation Ireland en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Acs Applied Nano Materials en
dc.internal.copyrightchecked Yes
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress en
dc.relation.project info:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2278/IE/Advanced Materials and BioEngineering Research Centre (AMBER)/ en

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