Nanosize and shape effects on antimicrobial activity of silver using morphology-controlled nanopatterns by block copolymer fabrication

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dc.contributor.author Ghoshal, Tandra
dc.contributor.author Cruz-Romero, Malco C.
dc.contributor.author Kerry, Joseph P.
dc.contributor.author Morris, Michael A.
dc.date.accessioned 2020-03-31T16:08:17Z
dc.date.available 2020-03-31T16:08:17Z
dc.date.issued 2019-10-04
dc.identifier.citation Ghoshal, T., Cruz-Romero, M. C., Kerry, J. P., Morris, M. A. (2019) 'Nanosize and Shape Effects on Antimicrobial Activity of Silver Using Morphology-Controlled Nanopatterns by Block Copolymer Fabrication', ACS Applied Nano Materials, 2 (10), pp. 6325-6333. doi: 10.1021/acsanm.9b01286 en
dc.identifier.volume 2 en
dc.identifier.issued 10 en
dc.identifier.startpage 6325 en
dc.identifier.endpage 6333 en
dc.identifier.issn 2574-0970
dc.identifier.uri http://hdl.handle.net/10468/9800
dc.identifier.doi 10.1021/acsanm.9b01286 en
dc.description.abstract The activity of silver nanomaterials as an antimicrobial is well-known with authors noting strong size and shape effects. This paper explores if the antimicrobial activity relates to unique size-related properties of the nanodimensioned materials or a more physical effect. Staphylococcus aureus and Pseudomonas aeruginosa were explored as test bacteria. They can cause serious human infections and are becoming resistant to pharmaceutical antimicrobials. Silver nanopatterns on a substrate surface were used as the antimicrobial agent. We demonstrate a cost-effective facile route to fabricate a well-ordered, periodic, and dimension-controlled silver lines and dots pattern on a substrate surface. This allowed precise definition of the silver materials to explore size and shape effects. Polystyrene-b-poly(ethylene oxide) (PS-b-PEO) block copolymer (BCP) microphase separated thin films were used as structural templates. Well-ordered PS-b-PEO thin film with vertical and parallel oriented PEO cylinders was achieved by a solvent vapor annealing approach through careful optimization of experimental parameters. A selective inclusion method (into one block of the BCP) of silver nitrate was used to generate the silver nanopatterns. Spin coating precursor-ethanol solution and subsequent UV/ozone treatment produce silver nanopattern arrays. They exhibited a significant growth-inhibitory effect on Staphylococcus aureus and Pseudomonas aeruginosa biofilms. However, data suggest this is associated with high surface area rather than a unique nanodimension related property change dictated by size or shape. en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher American Chemical Society en
dc.relation.uri https://pubs.acs.org/doi/abs/10.1021/acsanm.9b01286
dc.rights © 2019 American Chemical Society. This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Applied Nano Materials, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://pubs.acs.org/doi/abs/10.1021/acsanm.9b01286 en
dc.subject Antimicrobial en
dc.subject Block copolymer en
dc.subject Nanopatterns en
dc.subject Optical en
dc.subject Self-assembly en
dc.subject Silver en
dc.subject Substrate en
dc.subject Surface area en
dc.title Nanosize and shape effects on antimicrobial activity of silver using morphology-controlled nanopatterns by block copolymer fabrication en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Joseph Kerry, Dept Of Food & Nutritional Sciences, University College Cork, Cork, Ireland. +353-21-490-3000 Email: joe.kerry@ucc.ie en
dc.internal.availability Full text available en
dc.check.info Access to this article is restricted until 12 months after publication by request of the publisher. en
dc.check.date 2020-10-04
dc.date.updated 2020-03-31T15:49:43Z
dc.description.version Accepted Version en
dc.internal.rssid 500166380
dc.contributor.funder Science Foundation Ireland en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Acs Applied Nano Materials en
dc.internal.copyrightchecked Yes
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress joe.kerry@ucc.ie en
dc.relation.project info:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2278/IE/Advanced Materials and BioEngineering Research Centre (AMBER)/ en


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