Growth hormone treatment for non-GHD disorders: Excitement tempered by biology
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Published Version
Date
2023-07-14
Authors
Grimberg, Adda
Hawkes, Colin P.
Journal Title
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Volume Title
Publisher
Oxford University Press
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Abstract
The success of growth hormone (GH) replacement in children with classical GH deficiency has led to excitement that other causes of short stature may benefit similarly. However, clinical experience has shown less consistent and generally less dramatic effects on adult height, perhaps not surprising in light of increased understanding of GH and growth plate biology. Nonetheless, clinical demand for GH treatment continues to grow. Upon the 20th anniversary of the US Food and Drug Administration's approval of GH treatment for idiopathic short stature, this review will consider the factors underlying the expansion of GH treatment, the biological mechanisms of GH action, the non-GH–deficient uses of GH as a height-promoting agent, biological constraints to GH action, and future directions.
Description
Keywords
Growth hormone , Pediatric , Growth plate , Indications
Citation
Grimberg, A. and Hawkes, C. P. (2023) 'Growth hormone treatment for non-GHD disorders: Excitement tempered by biology', The Journal of Clinical Endocrinology & Metabolism, 109(2), e442–e454. https://doi.org/10.1210/clinem/dgad417
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Copyright
© 2023, the authors. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved.