Growth hormone treatment for non-GHD disorders: Excitement tempered by biology

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dc.check.date2024-07-14en
dc.check.infoAccess to this article is restricted until 12 months after publication by request of the publisheren
dc.contributor.authorGrimberg, Addaen
dc.contributor.authorHawkes, Colin P.en
dc.contributor.funderNational Institutes of Healthen
dc.date.accessioned2024-02-16T16:04:44Z
dc.date.available2024-02-16T16:04:44Z
dc.date.issued2023-07-14en
dc.description.abstractThe success of growth hormone (GH) replacement in children with classical GH deficiency has led to excitement that other causes of short stature may benefit similarly. However, clinical experience has shown less consistent and generally less dramatic effects on adult height, perhaps not surprising in light of increased understanding of GH and growth plate biology. Nonetheless, clinical demand for GH treatment continues to grow. Upon the 20th anniversary of the US Food and Drug Administration's approval of GH treatment for idiopathic short stature, this review will consider the factors underlying the expansion of GH treatment, the biological mechanisms of GH action, the non-GH–deficient uses of GH as a height-promoting agent, biological constraints to GH action, and future directions.en
dc.description.sponsorshipNational Institutes of Health (Grant 1 R01 HD097129 from the Eunice Kennedy Shriver National Institute of Child Health and Human Development)en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationGrimberg, A. and Hawkes, C. P. (2023) 'Growth hormone treatment for non-GHD disorders: Excitement tempered by biology', The Journal of Clinical Endocrinology & Metabolism, 109(2), e442–e454. https://doi.org/10.1210/clinem/dgad417en
dc.identifier.doihttps://doi.org/10.1210/clinem/dgad417en
dc.identifier.eissn1945-7197en
dc.identifier.endpagee454en
dc.identifier.issn0021-972Xen
dc.identifier.issued2en
dc.identifier.journaltitleThe Journal of Clinical Endocrinology & Metabolismen
dc.identifier.startpagee442en
dc.identifier.urihttps://hdl.handle.net/10468/15562
dc.identifier.volume109en
dc.language.isoenen
dc.publisherOxford University Pressen
dc.rights© 2023, the authors. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved.en
dc.subjectGrowth hormoneen
dc.subjectPediatricen
dc.subjectGrowth plateen
dc.subjectIndicationsen
dc.titleGrowth hormone treatment for non-GHD disorders: Excitement tempered by biologyen
dc.typeArticle (peer-reviewed)en
oaire.citation.issue2en
oaire.citation.volume109en
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