Sulfoxides: potent co-crystal formers

Eccles, Kevin S.; Elcoate, Curtis J.; Stokes, Stephen P.; Maguire, Anita R.; Lawrence, Simon E.

Sulfoxides: potent co-crystal formers

Files

KSE_SulfoxidesAV2010.pdf(135.37 KB)

Accepted Version

Date

2010-10

Authors

Eccles, Kevin S.

Elcoate, Curtis J.

Stokes, Stephen P.

Maguire, Anita R.

Lawrence, Simon E.

Publisher

American Chemical Society

Published Version

10.1021/cg1010192

Abstract

The design of co-crystals requires knowledge of robust supramol. synthons. The sulfoxide is a potent H bond acceptor and was used as a co-crystal former with a range of NH functional groups, via N-H···O=S H bonds. The NH functional group retains favorable H bond motifs from its own structure in all cases where this is possible, with the sulfoxide interacting in a discrete, capping fashion in four cases and in a bifurcated, bridging fashion in the three other cases presented here. Crystallog. data are given for 7 co-formers, dibenzyl sulfoxide and cyclohexanecarbothioamide.

Keywords

Crystallography and liquid crystals

Citation

ECCLES, K. S., ELCOATE, C. J., STOKES, S. P., MAGUIRE, A. R. & LAWRENCE, S. E. 2010. Sulfoxides: Potent Co-Crystal Formers. Crystal Growth & Design, 10, 4243-4245.

Copyright

© 2010, American Chemical Society. This document is the Accepted Manuscript version of a Published Work that appeared in final form in Crystal Growth & Design, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://pubs.acs.org/doi/abs/10.1021/cg1010192

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