Psychosocial, psychiatric and work-related risk factors associated with suicide in Ireland: Optimised methodological approach of a case-control psychological autopsy study

dc.contributor.authorArensman, Ella
dc.contributor.authorLarkin, C.
dc.contributor.authorMcCarthy, J.
dc.contributor.authorLeitao, Sara
dc.contributor.authorCorcoran, Paul
dc.contributor.authorWilliamson, Eileen
dc.contributor.authorMcAuliffe, C.
dc.contributor.authorPerry, Ivan J.
dc.contributor.authorGriffin, Eve
dc.contributor.authorCassidy, E. M.
dc.contributor.authorBradley, Colin
dc.contributor.authorKapur, N.
dc.contributor.authorKinahan, J.
dc.contributor.authorCleary, A.
dc.contributor.authorFoster, T.
dc.contributor.authorGallagher, Jonathan
dc.contributor.authorMalone, K.
dc.contributor.authorRamos Costa, Ana Paula
dc.contributor.authorGreiner, Birgit A.
dc.contributor.funderHealth Research Boarden
dc.contributor.funderNational Office for Suicide Preventionen
dc.description.abstractBackground: Suicide has profound effects on families and communities, but is a statistically rare event. Psychological autopsies using a case-control design allow researchers to examine risk factors for suicide, using a variety of sources to detail the psychological and social characteristics of decedents and to compare them to controls. The Suicide Support and Information System Case Control study (SSIS-ACE) aimed to compare psychosocial, psychiatric and work-related risk factors across three groups of subjects: suicide decedents, patients presenting to hospital with a high-risk self-harm episode, and general practice controls. Methods: The study design includes two inter-related studies; one main case-control study: comparing suicide cases to general practice (GP) controls, and one comparative study: comparing suicide cases to patients presenting with high-risk self-harm. Consecutive cases of suicide and probable suicide are identified through coroners’ registration of deaths in the defined region (Cork City and County, Ireland) and are frequency-matched for age group and gender with GP patient controls recruited from the same GP practice as the deceased. Data sources for suicide cases include coroners’ records, interviews with health care professionals and proxy informants; data sources for GP controls and for high-risk self-harm controls include interviews with control, with proxy informants and with health care professionals. Interviews are semi-structured and consist of quantitative and qualitative parts. The quantitative parts include a range of validated questionnaires addressing psychiatric, psychosocial and occupational factors. The study adopts several methodological innovations, including accessing multiple data sources for suicide cases and controls simultaneously, recruiting proxy informants to examine consistency across sources. Conclusions: The study allows for the investigation of consistency across different data sources and contributes to the methodological advancement of psychological autopsy research. The study will also inform clinical and public health practice. The comparison between suicide cases and controls will allow investigation of risk and protective factors for suicide more generally, while the comparison with high-risk self-harm patients will help to identify the factors associated specifically with a fatal outcome to a self-harm episode. A further enhancement is the particular focus on specific work-related risk factors for suicideen
dc.description.sponsorshipHealth Research Board (HRA-2013-PHR-438)en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.identifier.citationArensman, E., Larkin, C., McCarthy, J., Leitao, S., Corcoran, P., Williamson, E., McAuliffe, C., Perry, I. J., Griffin, E., Cassidy, E. M., Bradley, C., Kapur, N., Kinahan, J., Cleary, A., Foster, T., Gallagher, J., Malone, K., Ramos Costa, A. P. and Greiner, B. A. (2019) 'Psychosocial, psychiatric and work-related risk factors associated with suicide in Ireland: optimised methodological approach of a case-control psychological autopsy study', BMC Psychiatry, 19(1), 275. (11pp.) DOI: 10.1186/s12888-019-2249-6en
dc.identifier.journaltitleBMC Psychiatryen
dc.publisherBioMed Central Ltd.en
dc.rights© The Author(s) 2019. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.en
dc.subjectPsychological autopsyen
dc.subjectHigh-risk self-harmen
dc.subjectFamily informantsen
dc.titlePsychosocial, psychiatric and work-related risk factors associated with suicide in Ireland: Optimised methodological approach of a case-control psychological autopsy studyen
dc.typeArticle (peer-reviewed)en
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