Developing a new generation of therapeutic dental polymers to inhibit oral biofilms and protect teeth

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dc.contributor.authorZhang, Ke
dc.contributor.authorBaras, Bashayer
dc.contributor.authorLynch, Christopher D.
dc.contributor.authorWeir, Michael D.
dc.contributor.authorMelo, Mary Anne S.
dc.contributor.authorLi, Yuncong
dc.contributor.authorReynolds, Mark A.
dc.contributor.authorBai, Yuxing
dc.contributor.authorWang, Lin
dc.contributor.authorWang, Suping
dc.contributor.authorXu, Hockin H. K.
dc.contributor.funderNIH (US)en
dc.contributor.funderNational Science Foundation of Chinaen
dc.contributor.funderJilin Youth Fund of Science and Technologyen
dc.contributor.funderSchool of Dentistry, University of Marylanden
dc.date.accessioned2019-10-02T04:39:54Z
dc.date.available2019-10-02T04:39:54Z
dc.date.issued2018-09-17
dc.description.abstractPolymeric tooth-colored restorations are increasingly popular in dentistry. However, restoration failures remain a major challenge, and more than 50% of all operative work was devoted to removing and replacing the failed restorations. This is a heavy burden, with the expense for restoring dental cavities in the U.S. exceeding $46 billion annually. In addition, the need is increasing dramatically as the population ages with increasing tooth retention in seniors. Traditional materials for cavity restorations are usually bioinert and replace the decayed tooth volumes. This article reviews cutting-edge research on the synthesis and evaluation of a new generation of bioactive dental polymers that not only restore the decayed tooth structures, but also have therapeutic functions. These materials include polymeric composites and bonding agents for tooth cavity restorations that inhibit saliva-based microcosm biofilms, bioactive resins for tooth root caries treatments, polymers that can suppress periodontal pathogens, and root canal sealers that can kill endodontic biofilms. These novel compositions substantially inhibit biofilm growth, greatly reduce acid production and polysaccharide synthesis of biofilms, and reduce biofilm colony-forming units by three to four orders of magnitude. This new class of bioactive and therapeutic polymeric materials is promising to inhibit tooth decay, suppress recurrent caries, control oral biofilms and acid production, protect the periodontium, and heal endodontic infections.en
dc.description.sponsorshipNIH (R01 DE17974); NSFC (81400487, 81400540); Jilin Youth Fund of Science and Technology (20150520043JH)en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid1747en
dc.identifier.citationZhang, K., Baras, B., Lynch, C., Weir, M., Melo, M., Li, Y., Reynolds, M., Bai, Y., Wang, L., Wang, S. and Xu, H., 2018. Developing a new generation of therapeutic dental polymers to inhibit oral biofilms and protect teeth. Materials, 11(9),(1747). DOI:10.3390/ma11091747en
dc.identifier.doi10.3390/ma11091747en
dc.identifier.endpage17en
dc.identifier.issn1996-1944
dc.identifier.issued9en
dc.identifier.journaltitleMaterialsen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/8666
dc.identifier.volume11en
dc.language.isoenen
dc.publisherMDPI AGen
dc.relation.urihttps://www.mdpi.com/1996-1944/11/9/1747
dc.rights© 2018 by the authors. Licensee MDPI, Basel, Switzerland.en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectPolymeric compositesen
dc.subjectBonding agentsen
dc.subjectAntibacterialen
dc.subjectOral biofilmsen
dc.subjectPeriodontal pathogensen
dc.subjectCaries inhibitionen
dc.titleDeveloping a new generation of therapeutic dental polymers to inhibit oral biofilms and protect teethen
dc.typeArticle (peer-reviewed)en
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