Paediatric inflammatory bowel disease and its relationship with the microbiome

dc.contributor.authorFitzgerald, R. S.
dc.contributor.authorSanderson, Ian R.
dc.contributor.authorClaesson, Marcus J.
dc.contributor.funderIrish Research Councilen
dc.contributor.funderScience Foundation Irelanden
dc.contributor.funderCrohn's and Colitis Foundationen
dc.date.accessioned2022-11-08T14:10:45Z
dc.date.available2022-11-08T14:10:45Z
dc.date.issued2021-11
dc.date.updated2022-11-07T13:12:05Z
dc.description.abstractPaediatric inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the digestive tract, comprising of Crohn's disease (CD), ulcerative colitis (UC), and, where classification is undetermined, inflammatory bowel disease unclassified (IBDU). Paediatric IBD incidence is increasing globally, with prevalence highest in the developed world. Though no specific causative agent has been identified for paediatric IBD, it is believed that a number of factors may contribute to the development of the disease, including genetics and the environment. Another potential component in the development of IBD is the microbiota in the digestive tract, particularly the gut. While the exact role that the microbiome plays in IBD is unclear, many studies acknowledge the complex relationship between the gut bacteria and pathogenesis of IBD. In this review, we look at the increasing number of studies investigating the role the microbiome and other biomes play in paediatric patients with IBD, particularly changes associated with IBD, varying disease states, and therapeutics. The paediatric IBD microbiome is significantly different to that of healthy children, with decreased diversity and differences in bacterial composition (such as a decrease in Firmicutes). Changes in the microbiome relating to various treatments of IBD and disease severity have also been observed in multiple studies. Changes in diversity and composition may also extend to other biomes in paediatric IBD, such as the virome and the mycobiome. Research into biome differences in IBD paediatric patients may help progress our understanding of the aetiology of the disease.en
dc.description.sponsorshipIrish Research Council (Grant number GOIPG/2017/1573); Crohn’s and Colitis Foundation (Grant number 510264)en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationFitzgerald, R. S., Sanderson, I. R. and Claesson, Marcus J. (2021) 'Paediatric inflammatory bowel disease and its relationship with the microbiome', Microbial Ecology, 82, pp. 833–844. doi: 10.1007/s00248-021-01697-9en
dc.identifier.doi10.1007/s00248-021-01697-9en
dc.identifier.endpage844en
dc.identifier.issn0095-3628
dc.identifier.journaltitleMicrobial Ecologyen
dc.identifier.startpage833en
dc.identifier.urihttps://hdl.handle.net/10468/13835
dc.identifier.volume82en
dc.language.isoenen
dc.publisherSpringeren
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/en
dc.rights© The Author(s) 2021. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectGut microbiotaen
dc.subjectMicrobiomeen
dc.subjectPaediatric inflammatory bowel diseaseen
dc.subjectUlcerative colitisen
dc.subjectReviewen
dc.subjectCrohn’s diseaseen
dc.titlePaediatric inflammatory bowel disease and its relationship with the microbiomeen
dc.typeArticle (peer-reviewed)en
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