Gut microbiota alterations associated with reduced bone mineral density in older adults

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dc.contributor.authorDas, Mrinmoy
dc.contributor.authorCronin, Owen
dc.contributor.authorKeohane, David M.
dc.contributor.authorCormac, Edel M.
dc.contributor.authorNugent, Helena
dc.contributor.authorNugent, Michelle
dc.contributor.authorMolloy, Catherine
dc.contributor.authorO'Toole, Paul W.
dc.contributor.authorShanahan, Fergus
dc.contributor.authorMolloy, Michael G.
dc.contributor.authorJeffery, Ian B.
dc.contributor.fundericareen
dc.contributor.funderScience Foundation Irelanden
dc.date.accessioned2019-10-06T20:39:07Z
dc.date.available2019-10-06T20:39:07Z
dc.date.issued2019-08-04
dc.description.abstractObjective: To investigate compositional differences in the gut microbiota associated with bone homeostasis and fractures in a cohort of older adults. Methods: Faecal microbiota profiles were determined from 181 individuals with osteopenia (n = 61) or osteoporosis (n = 60), and an age- and gender-matched group with normal BMD (n = 60). Analysis of the 16S (V3-V4 region) amplicon dataset classified to the genus level was used to identify significantly differentially abundant taxa. Adjustments were made for potential confounding variables identified from the literature using several statistical models. Results: We identified six genera that were significantly altered in abundance in the osteoporosis or osteopenic groups compared with age- and gender-matched controls. A detailed study of microbiota associations with meta-data variables that included BMI, health status, diet and medication revealed that these meta-data explained 15–17% of the variance within the microbiota dataset. BMD measurements were significantly associated with alterations in the microbiota. After controlling for known biological confounders, five of the six taxa remained significant. Overall microbiota alpha diversity did not correlate to BMD in this study. Conclusion: Reduced BMD in osteopenia and osteoporosis is associated with an altered microbiota. These alterations may be useful as biomarkers or therapeutic targets in individuals at high risk of reductions in BMD. These observations will lead to a better understanding of the relationship between the microbiota and bone homeostasis.en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleidkez302en
dc.identifier.citationDas, M., Cronin, O., Keohane, D. M., Cormac, E. M., Nugent, H., Nugent, M., Molloy, C., O’Toole, P. W., Shanahan, F., Molloy, M. G. and Jeffery, I. B. (2019) 'Gut microbiota alterations associated with reduced bone mineral density in older adults', Rheumatology, kez302 (10pp) [In press]. DOI: 10.1093/rheumatology/kez302en
dc.identifier.doi10.1093/rheumatology/kez302en
dc.identifier.endpage10en
dc.identifier.issn1462-0324
dc.identifier.journaltitleRheumatologyen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/8695
dc.language.isoenen
dc.publisherBritish Society of Rheumatologyen
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/en
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Starting Investigator Research Grant (SIRG)/13/SIRG/2128/IE/Development of Knowledge Base Necessary for Novel Diagnostic and Therapeutic Pipeline for the Early Identification and Treatment of Rheumatoid Arthritis/en
dc.relation.urihttps://academic.oup.com/rheumatology/advance-article/doi/10.1093/rheumatology/kez302/5543609
dc.rights©The Author(s) 2019. Published by Oxford University Press on behalf of the British Society for Rheumatology. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.comen
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/en
dc.subjectOsteoporosisen
dc.subjectGut microbiotaen
dc.subjectBone mineral densityen
dc.subjectElderlyen
dc.subjectOsteopeniaen
dc.titleGut microbiota alterations associated with reduced bone mineral density in older adultsen
dc.typeArticle (peer-reviewed)en
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