Symposium: What does the microbiome tell us about prevention and treatment of AD/ADRD?

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Date
2024-10-09
Authors
Capocchi, Joia K.
Figueroa-Romero, Claudia
Dunham, Sage J. B.
Faraci, Gina
Rothman, Jason A.
Whiteson, Katrine L.
Seo, Dong-oh
Holtzman, David M.
Grabrucker, Stefanie
Nolan, Yvonne M.
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Society for Neuroscience
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Abstract
Alzheimer's disease (AD) and Alzheimer's disease-related dementias (ADRDs) are broad-impact multifactorial neurodegenerative diseases. Their complexity presents unique challenges for developing effective therapies. This review highlights research presented at the 2024 Society for Neuroscience meeting which emphasized the gut microbiome's role in AD pathogenesis by influencing brain function and neurodegeneration through the microbiota–gut–brain axis. This emerging evidence underscores the potential for targeting the gut microbiota to treat AD/ADRD.
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Keywords
Alzheimer's disease (AD) , Alzheimer's disease-related dementia (ADRD) , Gut microbiome , Brain function , Neurodegeneration , Microbiota–gut–brain axis
Citation
Capocchi, J. K., Figueroa-Romero, C., Dunham, S. J., Faraci, G., Rothman, J. A., Whiteson, K. L., Seo, D. O., Holtzman, D. M., Grabrucker, S., Nolan, Y. M. and Kaddurah-Daouk, R. (2024) 'SSymposium: What does the microbiome tell us about prevention and treatment of AD/ADRD?', Journal of Neuroscience, 44(41), e1295242024 (6pp). https://doi.org/10.1523/jneurosci.1295-24.2024
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© 2024, the Authors. Published by the Society for Neuroscience.