Towards micropump- and microneedle-based drug delivery using Micro Transdermal Interface Platforms (MicroTIPs)

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dc.contributor.authorTjulkins, Fjodors
dc.contributor.authorSebastian, Ryan
dc.contributor.authorGuillerm, Theo
dc.contributor.authorClover, A. James P.
dc.contributor.authorHu, Yu
dc.contributor.authorLyness, Alexander
dc.contributor.authorO'Mahony, Conor
dc.contributor.funderEnterprise Irelanden
dc.contributor.funderWest Pharmaceutical Services, Irelanden
dc.contributor.funderElectronic Components and Systems for European Leadershipen
dc.contributor.funderHorizon 2020en
dc.contributor.funderScience Foundation Irelanden
dc.date.accessioned2022-09-27T11:35:36Z
dc.date.available2022-09-27T11:35:36Z
dc.date.issued2022-07-15
dc.date.updated2022-09-27T11:20:35Z
dc.description.abstractMicro Transdermal Interface Platforms (MicroTIPs) will combine minimally invasive microneedle arrays with highly miniaturized sensors, actuators, control electronics, wireless communications and artificial intelligence. These patch-like devices will be capable of autonomous physiological monitoring and transdermal drug delivery, resulting in increased patient adherence and devolved healthcare. In this paper, we experimentally demonstrate the feasibility of controlled transdermal drug delivery using a combination of 500 μm tall silicon microneedles, a commercial micropump, pressure and flow sensors, and bespoke electronics. Using ex-vivo human skin samples and a customized application/retraction system, leak-free delivery of volumes ranging from 0.7-1.1 mL has been achieved in under one hour. Clinical Relevance — This work experimentally confirms the feasibility of combining micropumps with microneedle arrays for applications in transdermal drug delivery.en
dc.description.sponsorshipEnterprise Ireland and the ECSEL Joint Undertaking (under grant number H2020-ECSEL-2019-IA-876190 (Moore4Medical)); Enterprise Ireland and West Pharmaceutical Services (under grant number IP2017/0560); Science Foundation Ireland (SFI Insight Centre for Data Analytics (SFI/12/RC/2289-P2))en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationTjulkins, F., Sebastian, R., Guillerm, T., Clover, A. J. P., Hu, Y., Lyness, A. and O'Mahony, C. (2022) 'Towards Micropump- and Microneedle-based Drug Delivery using Micro Transdermal Interface Platforms (MicroTIPs)', 44th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (IEEE EMBC 2022), Glasgow, Scotland, UK, 11-15 July, pp. 3020-3023. doi: 10.1109/EMBC48229.2022.9871455en
dc.identifier.doi10.1109/EMBC48229.2022.9871455en
dc.identifier.eissn2694-0604
dc.identifier.endpage3023en
dc.identifier.isbn978-1-7281-2782-8
dc.identifier.startpage3020en
dc.identifier.urihttps://hdl.handle.net/10468/13673
dc.language.isoenen
dc.publisherIEEEen
dc.relation.ispartof2022 44th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)
dc.relation.projectinfo:eu-repo/grantAgreement/EC/H2020::ECSEL-IA/876190/EU/Accelerating Innovation in Microfabricated Medical Devices/Moore4Medicalen
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2289/IE/INSIGHT - Irelands Big Data and Analytics Research Centre/en
dc.relation.urihttps://doi.org/10.1109/EMBC48229.2022.9871455
dc.rights© 2022 The Authors. This work is licensed under a Creative Commons Attribution 3.0 License. For more information, see http://creativecommons.org/licenses/by/3.0/en
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/en
dc.subjectWireless communicationen
dc.subjectActuatorsen
dc.subjectWearable computersen
dc.subjectMicropumpsen
dc.subjectDrug deliveryen
dc.subjectSkinen
dc.subjectSiliconen
dc.subjectArtificial Intelligenceen
dc.subjectCommunicationen
dc.subjectDrug Delivery Systemsen
dc.subjectElectronicsen
dc.subjectHumansen
dc.subjectNeedlesen
dc.titleTowards micropump- and microneedle-based drug delivery using Micro Transdermal Interface Platforms (MicroTIPs)en
dc.typeConference itemen
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