A psychology of the human brain–gut–microbiome axis

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dc.contributor.authorAllen, Andrew P.
dc.contributor.authorDinan, Timothy G.
dc.contributor.authorClarke, Gerard
dc.contributor.authorCryan, John F.
dc.contributor.funderScience Foundation Irelanden
dc.contributor.funderSeventh Framework Programmeen
dc.contributor.funderEuropean Commissionen
dc.contributor.funderHealth Research Boarden
dc.contributor.funderHealth Service Executive, Irelanden
dc.date.accessioned2017-05-05T10:40:29Z
dc.date.available2017-05-05T10:40:29Z
dc.date.issued2017-04-18
dc.date.updated2017-05-05T10:29:02Z
dc.description.abstractIn recent years, we have seen increasing research within neuroscience and biopsychology on the interactions between the brain, the gastrointestinal tract, the bacteria within the gastrointestinal tract, and the bidirectional relationship between these systems: the brain–gut–microbiome axis. Although research has demonstrated that the gut microbiota can impact upon cognition and a variety of stress-related behaviours, including those relevant to anxiety and depression, we still do not know how this occurs. A deeper understanding of how psychological development as well as social and cultural factors impact upon the brain–gut–microbiome axis will contextualise the role of the axis in humans and inform psychological interventions that improve health within the brain–gut–microbiome axis. Interventions ostensibly aimed at ameliorating disorders in one part of the brain–gut–microbiome axis (e.g., psychotherapy for depression) may nonetheless impact upon other parts of the axis (e.g., microbiome composition and function), and functional gastrointestinal disorders such as irritable bowel syndrome represent a disorder of the axis, rather than an isolated problem either of psychology or of gastrointestinal function. The discipline of psychology needs to be cognisant of these interactions and can help to inform the future research agenda in this emerging field of research. In this review, we outline the role psychology has to play in understanding the brain–gut–microbiome axis, with a focus on human psychology and the use of research in laboratory animals to model human psychology.en
dc.description.sponsorshipScience Foundation Ireland (grant number SFI/12/RC/2273); Health Research Board (Health Research Awards (grant number HRA-POR-2-14-647; GC)); Health Service Executive (Healthy Ageing Award (HaPAI/2015/GC))en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationAllen, A. P., Dinan, T. G., Clarke, G. and Cryan, J. F. (2017) 'A psychology of the human brain–gut–microbiome axis', Social and Personality Psychology Compass, 11(4), e12309. doi:10.1111/spc3.12309en
dc.identifier.doi10.1111/spc3.12309
dc.identifier.endpagee12309-22en
dc.identifier.issn1751-9004
dc.identifier.issued4en
dc.identifier.journaltitleSocial and Personality Psychology Compassen
dc.identifier.startpagee12309-1en
dc.identifier.urihttps://hdl.handle.net/10468/3922
dc.identifier.volume11en
dc.language.isoenen
dc.publisherWileyen
dc.relation.projectinfo:eu-repo/grantAgreement/EC/FP7::SP1::KBBE/613979/EU/Microbiome Influence on Energy balance and Brain Development-Function Put into Action to Tackle Diet-related Diseases and Behavior./MYNEWGUTen
dc.rights© 2017 The Authors, Social and Personality Psychology Compass Published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectMicrobiomeen
dc.subjectBrain-gut-microbiome axisen
dc.subjectStressen
dc.subjectCognitionen
dc.subjectMooden
dc.titleA psychology of the human brain–gut–microbiome axisen
dc.typeArticle (peer-reviewed)en
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