T lymphocyte plasticity in chronic inflammatory diseases: The emerging role of the Ikaros family as a key Th17-Treg switch

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dc.contributor.authorRamón-Vázquez, Anaen
dc.contributor.authorFlood, Peteren
dc.contributor.authorCashman, Thuy Linhen
dc.contributor.authorP. Patilen
dc.contributor.authorGhosh, Subrataen
dc.contributor.funderScience Foundation Irelanden
dc.date.accessioned2025-01-14T12:55:12Z
dc.date.available2025-01-14T12:55:12Z
dc.date.issued2024-12-30en
dc.description.abstractT helper (Th) 17 and regulatory T (Treg) cells are highly plastic CD4+ Th cell subsets, being able not only to actively adapt to their microenvironment, but also to interconvert, acquiring mixed identity markers. These phenotypic changes are underpinned by transcriptional control mechanisms, chromatin reorganization events and epigenetic modifications, that can be hereditable and stable over time. The Ikaros family of transcription factors have a predominant role in T cell subset specification through mechanisms of transcriptional program regulation that enable phenotypical diversification. They are crucial factors in maintaining Th17/Treg balance and therefore, homeostatic conditions in the tissues. However, they are also implicated in pathogenic processes, where their transcriptional repression contributes to the control of autoimmune processes. In this review, we discuss how T cell fate, specifically in humans, is regulated by the Ikaros family and its interplay with additional factors like the Notch signaling pathway, gut microbiota and myeloid-T cell interactions. Further, we highlight how the transcriptional activity of the Ikaros family impacts the course of T cell mediated chronic inflammatory diseases like rheumatoid and psoriatic arthritis, inflammatory bowel disease, systemic lupus erythematosus and multiple sclerosis. We conclude by discussing recently developed therapeutics designed to target Ikaros family members.en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid103735en
dc.identifier.citationRamón-Vázquez, A., Flood, P., Cashman, T. L., Patil, P. and Ghosh, S. (2024) 'T lymphocyte plasticity in chronic inflammatory diseases: The emerging role of the Ikaros family as a key Th17-Treg switch', Autoimmunity Reviews, 24(3), 103735 (13pp). https://doi.org/10.1016/j.autrev.2024.103735en
dc.identifier.doihttps://doi.org/10.1016/j.autrev.2024.103735en
dc.identifier.endpage13en
dc.identifier.issn1568-9972en
dc.identifier.issued3en
dc.identifier.journaltitleAutoimmunity Reviewsen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/16816
dc.identifier.volume24en
dc.language.isoenen
dc.publisherElsevier B.V.en
dc.relation.ispartofAutoimmunity Reviewsen
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Professorship Programme/20/RP/9007/IE/Analytic Understanding of Gut Microenvironment to Enhance New Treatments (AUGMENT) Rational integration of precision nutrition, microbiome and immune response to optimise immunotherapy in IBD and other inflammatory diseases/en
dc.rights© 2025, the Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC license (https://creativecommons.org/licenses/by-nc/4.0/)en
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/en
dc.subjectT cell plasticityen
dc.subjectIkaros familyen
dc.subjectChronic inflammatory diseasesen
dc.subjectT cell differentiationen
dc.subjectTranscriptional controlen
dc.titleT lymphocyte plasticity in chronic inflammatory diseases: The emerging role of the Ikaros family as a key Th17-Treg switchen
dc.typeArticle (peer-reviewed)en
oaire.citation.issue3en
oaire.citation.volume24en
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