Genetic epidemiology of eating disorders

Bulik, Cynthia M.; Kleiman, Susan C.; Yilmaz, Zeynep

Genetic epidemiology of eating disorders

Files

nihms-852576.pdf(63.12 KB)

Accepted Version

Date

2016-11

Authors

Bulik, Cynthia M.

Kleiman, Susan C.

Yilmaz, Zeynep

Publisher

Wolters Kluwer Health, Inc.

Published Version

https://doi.org/10.1097/YCO.0000000000000275

Abstract

Purpose of review: We capture recent findings in the field of genetic epidemiology of eating disorders. As analytic techniques evolve for twin, population, and molecular genetic studies, new findings emerge at an accelerated pace. We present the current status of knowledge regarding the role of genetic and environmental factors that influence risk for eating disorders. Recent findings: We focus on novel findings from twin studies, population studies using genetically informative designs, and molecular genetic studies. Over the past 2 years, research in this area has yielded insights into: comorbidity with other psychiatric and medical disorders and with metabolic traits; developmental factors associated with the emergence of eating disorders; and the molecular genetics of anorexia nervosa. Summary: Insights from genetic epidemiology provide an important explanatory model for patients with eating disorders, family members, and clinicians. Understanding core biological determinants that explain the severity and persistence of the illnesses, their frequent co-occurrence with other conditions, and their familial patterns raises awareness and increases compassion for individuals living with these disorders. Large-scale genomic studies are currently underway. Ultimately, this domain of research may pave the way to greater understanding of the underlying neurobiology and inform the development of novel and effective interventions.

Keywords

Eating disorders , Genetic , GWAS , LD Score Regression , Comorbidity

Citation

Bulik, C. M., Kleiman, S. C. and Yilmaz, Z. (2016) 'Genetic epidemiology of eating disorders', Current Opinion in Psychiatry, 29(6), pp.383-388. https://doi.org/10.1097/YCO.0000000000000275