Genetic epidemiology of eating disorders

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dc.contributor.authorBulik, Cynthia M.en
dc.contributor.authorKleiman, Susan C.en
dc.contributor.authorYilmaz, Zeynepen
dc.contributor.funderVetenskapsrådeten
dc.contributor.funderKlarman Family Foundationen
dc.contributor.funderNational Institutes of Healthen
dc.date.accessioned2024-07-31T13:08:13Z
dc.date.available2024-07-31T13:08:13Z
dc.date.issued2016-11en
dc.description.abstractPurpose of review: We capture recent findings in the field of genetic epidemiology of eating disorders. As analytic techniques evolve for twin, population, and molecular genetic studies, new findings emerge at an accelerated pace. We present the current status of knowledge regarding the role of genetic and environmental factors that influence risk for eating disorders. Recent findings: We focus on novel findings from twin studies, population studies using genetically informative designs, and molecular genetic studies. Over the past 2 years, research in this area has yielded insights into: comorbidity with other psychiatric and medical disorders and with metabolic traits; developmental factors associated with the emergence of eating disorders; and the molecular genetics of anorexia nervosa. Summary: Insights from genetic epidemiology provide an important explanatory model for patients with eating disorders, family members, and clinicians. Understanding core biological determinants that explain the severity and persistence of the illnesses, their frequent co-occurrence with other conditions, and their familial patterns raises awareness and increases compassion for individuals living with these disorders. Large-scale genomic studies are currently underway. Ultimately, this domain of research may pave the way to greater understanding of the underlying neurobiology and inform the development of novel and effective interventions.en
dc.description.sponsorshipVetenskapsrådet (VR Dnr: 538-2013-8864); National Institutes of Health (T32MH076694; K01 MH109782)en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationBulik, C. M., Kleiman, S. C. and Yilmaz, Z. (2016) 'Genetic epidemiology of eating disorders', Current Opinion in Psychiatry, 29(6), pp.383-388. https://doi.org/10.1097/YCO.0000000000000275en
dc.identifier.doihttps://doi.org/10.1097/YCO.0000000000000275en
dc.identifier.endpage388en
dc.identifier.issn0951-7367en
dc.identifier.issued6en
dc.identifier.journaltitleCurrent Opinion in Psychiatryen
dc.identifier.startpage383en
dc.identifier.urihttps://hdl.handle.net/10468/16171
dc.identifier.volume29en
dc.language.isoenen
dc.publisherWolters Kluwer Health, Inc.en
dc.rights© 2016, Wolters Kluwer Health, Inc.en
dc.subjectEating disordersen
dc.subjectGeneticen
dc.subjectGWASen
dc.subjectLD Score Regressionen
dc.subjectComorbidityen
dc.titleGenetic epidemiology of eating disordersen
dc.typeArticle (peer-reviewed)en
oaire.citation.issue6en
oaire.citation.volume29en
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