The association of night-time systolic blood pressure with ultrasound markers of subclinical cardiac and vascular disease

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dc.contributor.authorO'Flynn, Anne Marie
dc.contributor.authorHo, Emily
dc.contributor.authorDolan, Eamon
dc.contributor.authorCurtin, Ronan J.
dc.contributor.authorKearney, Patricia M.
dc.contributor.funderHealth Research Board
dc.contributor.funderIrish Heart Foundation
dc.date.accessioned2018-06-15T11:47:15Z
dc.date.available2018-06-15T11:47:15Z
dc.date.issued2017
dc.description.abstractIntroduction The aim of this study was to examine the association of night-time systolic blood pressure (BP) with subclinical cardiac dysfunction measured by global longitudinal strain (GLS) and subclinical vascular damage measured by carotid intima-media thickness (CIMT) and carotid plaques. Methods GLS was measured by speckle-tracking analysis of echocardiogram images. CIMT was measured at the distal 1 cm of the common carotid artery. The presence of carotid plaques was recorded. Philips QLAB cardiac and vascular ultrasound quantification software was used for analysis. The association of night-time systolic BP with GLS, CIMT and carotid plaques was assessed using linear and logistic regression. Results Fifty (response rate 63%) individuals took part in this study. In univariable models, night-time systolic BP was significantly associated with GLS [beta coefficient 0.85 for every 10 mmHg increase, 95% confidence interval (CI): 0.3-1.4] and carotid plaques (odds ratio 1.9 for every 10 mmHg increase, 95% CI: 1.1-3.2). Univariable analysis of daytime systolic BP did not show any statistically significant associations. In age-adjusted and sex-adjusted models, the association for night-time systolic BP and GLS remained significant (beta coefficient 0.68 for every 10 mmHg increase, 95% CI: 0.1-1.3). The association for carotid plaques was no longer statistically significant. In multivariable models, findings were diminished. Discussion Our results suggest a trend towards an association between night-time systolic BP and subclinical cardiac and vascular disease. When assessing ambulatory blood pressure monitoring results, the absolute night-time systolic BP seems to be a better prognostic parameter than daytime systolic BP, but ultimately a large randomised controlled trial involving chronotherapy is necessary to fully address this. Copyright (C) 2017 Wolters Kluwer Health, Inc. All rights reserved.en
dc.description.sponsorshipHealth Research Board (HPF/2012/14); Irish Heart Foundation (John Feely research bursary)en
dc.description.statusPeer reviewed
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationO’Flynn, A. M., Ho, E., Dolan, E., Curtin, R. J. and Kearney, P. M. (2017) 'The association of night-time systolic blood pressure with ultrasound markers of subclinical cardiac and vascular disease', Blood Pressure Monitoring, 22(1), pp. 18-26. doi: 10.1097/MBP.0000000000000223en
dc.identifier.doi10.1097/MBP.0000000000000223
dc.identifier.endpage26
dc.identifier.issn1359-5237
dc.identifier.issued1
dc.identifier.journaltitleBlood Pressure Monitoringen
dc.identifier.startpage18
dc.identifier.urihttps://hdl.handle.net/10468/6342
dc.identifier.volume22
dc.language.isoenen
dc.publisherLippincott, Williams & Wilkinsen
dc.relation.urihttps://journals.lww.com/bpmonitoring/Fulltext/2017/02000/The_association_of_night_time_systolic_blood.4.aspx
dc.rights© 2017, the Authors. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectAmbulatory blood pressure monitoringen
dc.subjectCarotid intima-media thicknessen
dc.subjectGlobal longitudinal strainen
dc.subjectHypertensionen
dc.subjectUltrasonographyen
dc.titleThe association of night-time systolic blood pressure with ultrasound markers of subclinical cardiac and vascular diseaseen
dc.typeArticle (peer-reviewed)en
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