Antenatal vitamin D status is not associated with standard neurodevelopmental assessments at age 5 Years in a well-characterized prospective maternal-infant cohort

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dc.contributor.authorMcCarthy, Elaine K.
dc.contributor.authorMalvisi, Lucio
dc.contributor.authorKiely, Mairead E.
dc.contributor.authorMurray, Deirdre M.
dc.contributor.authorHourihane, Jonathan O'B.
dc.contributor.authorIrvine, Alan D.
dc.contributor.authorKenny, Louise C.
dc.contributor.funderSeventh Framework Programmeen
dc.contributor.funderNational Children’s Research Centre, Irelanden
dc.contributor.funderHealth Research Boarden
dc.contributor.funderScience Foundation Irelanden
dc.date.accessioned2019-02-18T16:25:48Z
dc.date.available2019-02-18T16:25:48Z
dc.date.issued2018-08-30
dc.date.updated2019-02-18T16:11:36Z
dc.description.abstractBackground: Although animal studies show evidence for a role of vitamin D during brain development, data from human studies show conflicting signals. Objective: We aimed to explore associations between maternal and neonatal vitamin D status with childhood neurodevelopmental outcomes. Methods: Comprehensive clinical, demographic, and lifestyle data were collected prospectively in 734 maternal-infant dyads from the Cork BASELINE Birth Cohort Study. Serum 25-hydroxyvitamin D [25(OH)D] concentrations were quantified at 15 weeks of gestation and in umbilical cord sera at birth via a CDC-accredited liquid chromatography-tandem mass spectrometry method. Children were assessed at age 5 y through the use of the Kaufman Brief Intelligence Test (2nd Edition, KBIT-2) and the Child Behaviour Checklist (CBCL). Linear regression was used to explore associations between 25(OH)D and neurodevelopmental outcomes. Results: 25(OH)D concentrations were <30 nmol/L in 15% of maternal and 45% of umbilical cord sera and <50 nmol/L in 42% of mothers and 80% of cords. At age 5 y, the mean ± SD KBIT-2 intelligence quotient (IQ) composite score was 104.6 ± 8.6; scores were 107.2 ± 10.0 in verbal and 99.8 ± 8.8 in nonverbal tasks. Developmental delay (scores <85) was seen in <3% of children across all domains. The mean ± SD CBCL total problem score was 21.3 ± 17.5; scores in the abnormal/clinical range for internal, external, and total problem scales were present in 12%, 4%, and 6% of participants, respectively. KBIT-2 and CBCL subscale scores at 5 y were not different between children exposed to low antenatal vitamin D status, either at 30 or 50 nmol/L 25(OH)D thresholds. Neither maternal nor cord 25(OH)D (per 10 nmol/L) were associated with KBIT-2 IQ composite scores [adjusted β (95% CI): maternal –0.01 (−0.03, 0.02); cord 0.01 (−0.03, 0.04] or CBCL total problem scores [maternal 0.01 (−0.04, 0.05); cord 0.01 (−0.07, 0.09)]. Conclusion: In this well-characterized prospective maternal-infant cohort, we found no evidence that antenatal 25(OH)D concentrations are associated with neurodevelopmental outcomes at 5 y. The BASELINE Study was registered at www.clinicaltrials.gov as NCT01498965; the SCOPE Study was registered at http://www.anzctr.org.au as ACTRN12607000551493en
dc.description.sponsorshipHealth Research Board, Ireland (grant CSA 02/2007)en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationMcCarthy, E. K., Malvisi, L., Kiely, M. E., Murray, D. M., O'B Hourihane, J., Irvine, A. D. and Kenny, L. C. (2018) 'Antenatal Vitamin D Status Is Not Associated with Standard Neurodevelopmental Assessments at Age 5 Years in a Well-Characterized Prospective Maternal-Infant Cohort', The Journal of Nutrition, 148(10), pp. 1580-1586. doi: 10.1093/jn/nxy150en
dc.identifier.doi10.1093/jn/nxy150
dc.identifier.endpage1586en
dc.identifier.issn0022-3166
dc.identifier.issued10en
dc.identifier.journaltitleJournal of Nutritionen
dc.identifier.startpage1580en
dc.identifier.urihttps://hdl.handle.net/10468/7513
dc.identifier.volume148en
dc.language.isoenen
dc.publisherOxford University Pressen
dc.relation.projectinfo:eu-repo/grantAgreement/EC/FP7::SP1::KBBE/613977/EU/Food-based solutions for Optimal vitamin D Nutrition and health through the life cycle/ODINen
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2272/IE/Irish Centre for Fetal and Neonatal Translational Research (INFANT)/en
dc.relation.urihttps://academic.oup.com/jn/article/148/10/1580/5087688
dc.rights© 2018 American Society for Nutrition. This is a pre-copyedited, author-produced PDF of an article accepted for publication in Journal of Nutrition] following peer review. The version of record is available online at: https://academic.oup.com/jn/article/148/10/1580/5087688en
dc.subjectVitamin Den
dc.subjectSerum 25-hydroxyvitamin Den
dc.subjectNeurodevelopmenten
dc.subjectIntelligenceen
dc.subjectAntenatalen
dc.subjectPregnancyen
dc.subjectChilden
dc.subjectInfanten
dc.subjectNewbornen
dc.subjectIntelligenceen
dc.subjectIntelligence testsen
dc.subjectMothersen
dc.subjectUmbilical corden
dc.subjectPrenatal careen
dc.subjectBirthen
dc.subjectPrimary cutaneous b-cell lymphomaen
dc.subjectChild behavior checklisten
dc.subject25-hydroxyvitamin den
dc.titleAntenatal vitamin D status is not associated with standard neurodevelopmental assessments at age 5 Years in a well-characterized prospective maternal-infant cohorten
dc.typeArticle (peer-reviewed)en
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