Antenatal vitamin D status is not associated with standard neurodevelopmental assessments at age 5 Years in a well-characterized prospective maternal-infant cohort

McCarthy, Elaine K.; Malvisi, Lucio; Kiely, Mairead E.; Murray, Deirdre M.; Hourihane, Jonathan O'B.; Irvine, Alan D.; Kenny, Louise C.

Access to this article is restricted until 12 months after publication at the request of the publisher. Restriction lift date: 2019-08-30

Antenatal vitamin D status is not associated with standard neurodevelopmental assessments at age 5 Years in a well-characterized prospective maternal-infant cohort

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dc.check.date	2019-08-30
dc.check.info	Access to this article is restricted until 12 months after publication at the request of the publisher	en
dc.contributor.author	McCarthy, Elaine K.
dc.contributor.author	Malvisi, Lucio
dc.contributor.author	Kiely, Mairead E.
dc.contributor.author	Murray, Deirdre M.
dc.contributor.author	Hourihane, Jonathan O'B.
dc.contributor.author	Irvine, Alan D.
dc.contributor.author	Kenny, Louise C.
dc.contributor.funder	Seventh Framework Programme	en
dc.contributor.funder	National Children’s Research Centre, Ireland	en
dc.contributor.funder	Health Research Board	en
dc.contributor.funder	Science Foundation Ireland	en
dc.date.accessioned	2019-02-18T16:25:48Z
dc.date.available	2019-02-18T16:25:48Z
dc.date.issued	2018-08-30
dc.date.updated	2019-02-18T16:11:36Z
dc.description.abstract	Background: Although animal studies show evidence for a role of vitamin D during brain development, data from human studies show conflicting signals. Objective: We aimed to explore associations between maternal and neonatal vitamin D status with childhood neurodevelopmental outcomes. Methods: Comprehensive clinical, demographic, and lifestyle data were collected prospectively in 734 maternal-infant dyads from the Cork BASELINE Birth Cohort Study. Serum 25-hydroxyvitamin D [25(OH)D] concentrations were quantified at 15 weeks of gestation and in umbilical cord sera at birth via a CDC-accredited liquid chromatography-tandem mass spectrometry method. Children were assessed at age 5 y through the use of the Kaufman Brief Intelligence Test (2nd Edition, KBIT-2) and the Child Behaviour Checklist (CBCL). Linear regression was used to explore associations between 25(OH)D and neurodevelopmental outcomes. Results: 25(OH)D concentrations were <30 nmol/L in 15% of maternal and 45% of umbilical cord sera and <50 nmol/L in 42% of mothers and 80% of cords. At age 5 y, the mean ± SD KBIT-2 intelligence quotient (IQ) composite score was 104.6 ± 8.6; scores were 107.2 ± 10.0 in verbal and 99.8 ± 8.8 in nonverbal tasks. Developmental delay (scores <85) was seen in <3% of children across all domains. The mean ± SD CBCL total problem score was 21.3 ± 17.5; scores in the abnormal/clinical range for internal, external, and total problem scales were present in 12%, 4%, and 6% of participants, respectively. KBIT-2 and CBCL subscale scores at 5 y were not different between children exposed to low antenatal vitamin D status, either at 30 or 50 nmol/L 25(OH)D thresholds. Neither maternal nor cord 25(OH)D (per 10 nmol/L) were associated with KBIT-2 IQ composite scores [adjusted β (95% CI): maternal –0.01 (−0.03, 0.02); cord 0.01 (−0.03, 0.04] or CBCL total problem scores [maternal 0.01 (−0.04, 0.05); cord 0.01 (−0.07, 0.09)]. Conclusion: In this well-characterized prospective maternal-infant cohort, we found no evidence that antenatal 25(OH)D concentrations are associated with neurodevelopmental outcomes at 5 y. The BASELINE Study was registered at www.clinicaltrials.gov as NCT01498965; the SCOPE Study was registered at http://www.anzctr.org.au as ACTRN12607000551493	en
dc.description.sponsorship	Health Research Board, Ireland (grant CSA 02/2007)	en
dc.description.status	Peer reviewed	en
dc.description.version	Accepted Version	en
dc.format.mimetype	application/pdf	en
dc.identifier.citation	McCarthy, E. K., Malvisi, L., Kiely, M. E., Murray, D. M., O'B Hourihane, J., Irvine, A. D. and Kenny, L. C. (2018) 'Antenatal Vitamin D Status Is Not Associated with Standard Neurodevelopmental Assessments at Age 5 Years in a Well-Characterized Prospective Maternal-Infant Cohort', The Journal of Nutrition, 148(10), pp. 1580-1586. doi: 10.1093/jn/nxy150	en
dc.identifier.doi	10.1093/jn/nxy150
dc.identifier.endpage	1586	en
dc.identifier.issn	0022-3166
dc.identifier.issued	10	en
dc.identifier.journaltitle	Journal of Nutrition	en
dc.identifier.startpage	1580	en
dc.identifier.uri	https://hdl.handle.net/10468/7513
dc.identifier.volume	148	en
dc.language.iso	en	en
dc.publisher	Oxford University Press	en
dc.relation.project	info:eu-repo/grantAgreement/EC/FP7::SP1::KBBE/613977/EU/Food-based solutions for Optimal vitamin D Nutrition and health through the life cycle/ODIN	en
dc.relation.project	info:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2272/IE/Irish Centre for Fetal and Neonatal Translational Research (INFANT)/	en
dc.relation.uri	https://academic.oup.com/jn/article/148/10/1580/5087688
dc.rights	© 2018 American Society for Nutrition. This is a pre-copyedited, author-produced PDF of an article accepted for publication in Journal of Nutrition] following peer review. The version of record is available online at: https://academic.oup.com/jn/article/148/10/1580/5087688	en
dc.subject	Vitamin D	en
dc.subject	Serum 25-hydroxyvitamin D	en
dc.subject	Neurodevelopment	en
dc.subject	Intelligence	en
dc.subject	Antenatal	en
dc.subject	Pregnancy	en
dc.subject	Child	en
dc.subject	Infant	en
dc.subject	Newborn	en
dc.subject	Intelligence	en
dc.subject	Intelligence tests	en
dc.subject	Mothers	en
dc.subject	Umbilical cord	en
dc.subject	Prenatal care	en
dc.subject	Birth	en
dc.subject	Primary cutaneous b-cell lymphoma	en
dc.subject	Child behavior checklist	en
dc.subject	25-hydroxyvitamin d	en
dc.title	Antenatal vitamin D status is not associated with standard neurodevelopmental assessments at age 5 Years in a well-characterized prospective maternal-infant cohort	en
dc.type	Article (peer-reviewed)	en