Dietary conjugated linoleic acid-enriched cheeses influence the levels of circulating n-3 highly unsaturated fatty acids in humans

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dc.contributor.authorMurru, Elisabetta
dc.contributor.authorCarta, Gianfranca
dc.contributor.authorCordeddu, Lina
dc.contributor.authorMelis, Maria Paola
dc.contributor.authorDesogus, Erika
dc.contributor.authorAnsar, Hastimansooreh
dc.contributor.authorChilliard, Yves
dc.contributor.authorFerlay, Anne
dc.contributor.authorStanton, Catherine
dc.contributor.authorCoakley, Mairead
dc.contributor.authorRoss, R. Paul
dc.contributor.authorPiredda, Giovanni
dc.contributor.authorAddis, Margherita
dc.contributor.authorMele, Maria Cristina
dc.contributor.authorCannelli, Giorgio
dc.contributor.authorBanni, Sebastiano
dc.contributor.authorManca, Claudia
dc.contributor.funderFifth Framework Programme
dc.contributor.funderScience Foundation Ireland
dc.contributor.funderEuropean Regional Development Fund
dc.date.accessioned2018-09-20T15:53:43Z
dc.date.available2018-09-20T15:53:43Z
dc.date.issued2018
dc.description.abstractn-3 highly unsaturated fatty acids (n-3 HUFA) directly and indirectly regulate lipid metabolism, energy balance and the inflammatory response. We investigated changes to the n-3 HUFA score of healthy adults, induced by different types and amounts of conjugated linoleic acid (CLA)-enriched (ENCH) cheeses consumed for different periods of time, compared to dietary fish oil (FO) pills (500 mg, each containing 100 mg of eicosapentaenoic and docosahexaenoic acidsEPA+DHA) or -linolenic acid (ALA)-rich linseed oil (4 g, containing 2 g of ALA). A significant increase in the n-3 HUFA score was observed, in a dose-dependent manner, after administration of the FO supplement. In terms of the impact on the n-3 HUFA score, the intake of ENCH cheese (90 g/day) for two or four weeks was equivalent to the administration of one or two FO pills, respectively. Conversely, the linseed oil intake did not significantly impact the n-3 HUFA score. Feeding ENCH cheeses from different sources (bovine, ovine and caprine) for two months improved the n-3 HUFA score by increasing plasma DHA, and the effect was proportional to the CLA content in the cheese. We suggest that the improved n-3 HUFA score resulting from ENCH cheese intake may be attributed to increased peroxisome proliferator-activated receptor alpha (PPAR-) activity. This study demonstrates that natural ENCH cheese is an alternative nutritional source of n-3 HUFA in humans.en
dc.description.sponsorshipFifth Framework Programme (QLK1-2002-02362); European Regional Development Fund (INNOVA.RE-WP 2.3-P.O.R.-F.E.S.R.)en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid1730
dc.identifier.citationMurru, E., Carta, G., Cordeddu, L., Melis, M., Desogus, E., Ansar, H., Chilliard, Y., Ferlay, A., Stanton, C., Coakley, M., Ross, R., Piredda, G., Addis, M., Mele, M., Cannelli, G., Banni, S. and Manca, C. (2018) 'Dietary conjugated linoleic acid-enriched cheeses influence the levels of circulating n-3 highly unsaturated fatty acids in humans', International Journal of Molecular Sciences, 19(6), 1730 (16pp). doi: 10.3390/ijms19061730en
dc.identifier.doi10.3390/ijms19061730
dc.identifier.endpage16
dc.identifier.issn1422-0067
dc.identifier.issued6
dc.identifier.journaltitleInternational Journal of Molecular Sciencesen
dc.identifier.startpage1
dc.identifier.urihttps://hdl.handle.net/10468/6837
dc.identifier.volume19
dc.language.isoenen
dc.publisherMDPIen
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/
dc.relation.urihttp://www.mdpi.com/1422-0067/19/6/1730
dc.rights© 2018, the Authors. Licensee MDPI, Basel, Switzerland. This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectConjugated linoleic acids (CLA)en
dc.subjectCheeseen
dc.subjectRuminanten
dc.subjectHighly unsaturated fatty acids (HUFA)en
dc.subjectFatty acids (FA)en
dc.subjectPlasmaen
dc.subjectClinical trialen
dc.titleDietary conjugated linoleic acid-enriched cheeses influence the levels of circulating n-3 highly unsaturated fatty acids in humansen
dc.typeArticle (peer-reviewed)en
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