Bacterial modulation of visceral sensation: mediators and mechanisms

dc.check.date2020-07-10
dc.check.infoAccess to this article is restricted until 12 months after publication by request of the publisher.en
dc.contributor.authorLomax, Alan E.
dc.contributor.authorPradhananga, Sabindra
dc.contributor.authorSessenwein, Jessica L.
dc.contributor.authorO'Malley, Dervla
dc.date.accessioned2019-08-30T14:15:48Z
dc.date.available2019-08-30T14:15:48Z
dc.date.issued2019-07-10
dc.date.updated2019-08-30T14:10:03Z
dc.description.abstractThe potential role of the intestinal microbiota in modulating visceral pain has received increasing attention during recent years. This has led to the identification of signaling pathways that have been implicated in communication between gut bacteria and peripheral pain pathways. In addition to the well-characterised impact of the microbiota on the immune system, which in turn affects nociceptor excitability, bacteria can modulate visceral afferent pathways by effects on enterocytes, enteroendocrine cells and the neurons themselves. Proteases produced by bacteria, or by host cells in response to bacteria, can increase or decrease the excitability of nociceptive dorsal root ganglion (DRG) neurons depending on the receptor activated. Short chain fatty acids generated by colonic bacteria are involved in gut-brain communication, and intracolonic short chain fatty acids have pro-nociceptive effects in rodents but may be anti-nociceptive in humans. Gut bacteria modulate the synthesis and release of enteroendocrine cell mediators including serotonin and glucagon-like peptide-1, which activate extrinsic afferent neurons. Deciphering the complex interactions between visceral afferent neurons and the gut microbiota may lead to the development of improved probiotic therapies for visceral pain.en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationLomax, A. E., Pradhananga, S., Sessenwein, J. L. and O'Malley, D. (2019) 'Bacterial modulation of visceral sensation: mediators and mechanisms', American Journal of Physiology-Gastrointestinal and Liver Physiology, In Press, doi: 10.1152/ajpgi.00052.2019en
dc.identifier.doi10.1152/ajpgi.00052.2019en
dc.identifier.endpage31en
dc.identifier.issn0002-9513
dc.identifier.journaltitleAmerican Journal Of Physiology-Gastrointestinal And Liver Physiologyen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/8423
dc.language.isoenen
dc.publisherAmerican Physiological Societyen
dc.relation.urihttps://www.physiology.org/doi/abs/10.1152/ajpgi.00052.2019
dc.rights© 2019, The American Physiological Society. All rights reserved.en
dc.subjectMicrobiotaen
dc.subjectVisceral sensationen
dc.subjectProteasesen
dc.subjectSerotoninen
dc.subjectHost-microbe interactionen
dc.titleBacterial modulation of visceral sensation: mediators and mechanismsen
dc.typeArticle (peer-reviewed)en
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