A biological framework for emotional dysregulation in alcohol misuse: from gut to brain

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dc.contributor.authorCarbia, Carinaen
dc.contributor.authorLannoy, Séverineen
dc.contributor.authorMaurage, Pierreen
dc.contributor.authorLópez-Caneda, Eduardoen
dc.contributor.authorO'Riordan, Kenneth J.en
dc.contributor.authorDinan, Timothy G.en
dc.contributor.authorCryan, John F.en
dc.contributor.funderHorizon 2020en
dc.contributor.funderBelgian American Educational Foundationen
dc.contributor.funderFonds De La Recherche Scientifique - FNRSen
dc.contributor.funderFundação para a Ciência e a Tecnologiaen
dc.date.accessioned2023-06-14T14:00:32Z
dc.date.available2023-06-14T14:00:32Z
dc.date.issued2020-12-07en
dc.description.abstractAlcohol use disorder (AUD) has been associated with impairments in social and emotional cognition that play a crucial role in the development and maintenance of addiction. Repeated alcohol intoxications trigger inflammatory processes and sensitise the immune system. In addition, emerging data point to perturbations in the gut microbiome as a key regulator of the inflammatory cascade in AUD. Inflammation and social cognition are potent modulators of one another. At the same time, accumulating evidence implicates the gut microbiome in shaping emotional and social cognition, suggesting the possibility of a common underlying loop of crucial importance for addiction. Here we propose an integrative microbiome neuro-immuno-affective framework of how emotional dysregulation and alcohol-related microbiome dysbiosis could accelerate the cycle of addiction. We outline the overlapping effects of chronic alcohol use, inflammation and microbiome alterations on the fronto-limbic circuitry as a convergence hub for emotional dysregulation. We discuss the interdependent relationship of social cognition, immunity and the microbiome in relation to alcohol misuse- from binge drinking to addiction. In addition, we emphasise adolescence as a sensitive period for the confluence of alcohol harmful effects and emotional dysregulation in the developing gut-brain axis.en
dc.description.sponsorshipFundação para a Ciência e a Tecnologia (CEECIND/02979/2018)en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationCarbia, C., Lannoy, S., Maurage, P., López-Caneda, E., O’Riordan, K. J., Dinan, T. G. and Cryan, J. F. (2021) 'A biological framework for emotional dysregulation in alcohol misuse: from gut to brain', Molecular Psychiatry, 26(4), pp.1098-1118. doi: 10.1038/s41380-020-00970-6en
dc.identifier.doi10.1038/s41380-020-00970-6en
dc.identifier.eissn1476-5578en
dc.identifier.endpage1118en
dc.identifier.issn1359-4184en
dc.identifier.issued4en
dc.identifier.journaltitleMolecular Psychiatryen
dc.identifier.startpage1098en
dc.identifier.urihttps://hdl.handle.net/10468/14584
dc.identifier.volume26en
dc.language.isoenen
dc.publisherSpringer Nature Ltd.en
dc.relation.projectinfo:eu-repo/grantAgreement/EC/H2020::MSCA-COFUND-FP/754535/EU/APC Postdoctoral EXcellence Programme/APEXen
dc.rights© 2020, Springer Nature Limited. This is a post-peer-review, pre-copyedit version of an article published in Molecular Psychiatry. The final authenticated version is available online at: https://doi.org/10.1038/s41380-020-00970-6en
dc.subjectChronic alcohol useen
dc.subjectInflammationen
dc.subjectMicrobiome alterations on the fronto-limbic circuitryen
dc.subjectEmotional dysregulationen
dc.subjectMicrobiomeen
dc.subjectGut-brain axisen
dc.subjectAdolescenceen
dc.titleA biological framework for emotional dysregulation in alcohol misuse: from gut to brainen
dc.typeArticle (peer-reviewed)en
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