Exposure to hypertensive disorders of pregnancy increases the risk of autism spectrum disorder in affected offspring

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dc.contributor.authorCurran, Eileen A.
dc.contributor.authorO'Keeffe, Gerard W.
dc.contributor.authorLooney, Ann-Marie
dc.contributor.authorMoloney, Gerard M.
dc.contributor.authorHegarty, Shane V.
dc.contributor.authorMurray, Deirdre M.
dc.contributor.authorKhashan, Ali S.
dc.contributor.authorKenny, Louise C.
dc.contributor.funderScience Foundation Irelanden
dc.date.accessioned2018-01-30T11:42:44Z
dc.date.available2018-01-30T11:42:44Z
dc.date.issued2017-10-03
dc.date.updated2018-01-30T09:44:54Z
dc.description.abstractThere is growing awareness that prenatal adversity may increase the risk of autism spectrum disorder (ASD). Here, we examined the association between hypertensive disorders of pregnancy (HDP) and ASD risk at 7 years of age using the Millennium Cohort Study (MCS), a representative cohort of 13,192 children born in the UK from 2000 to 2001. We also sought to examine cytokine expression in the serum of women with pre-eclampsia, which is the most common HDP, and whether exposure of foetal neurons to this serum could change patterns of neuronal growth. HDP were reported by mothers 9 months post-delivery. ASD was parent reported at age seven, based on a doctor or health care professional’s diagnosis. Weighted logistic regression was used for data analysis, adjusting for several potential confounders including maternal alcohol consumption, education, depression, age, and poverty status. Sensitivity analyses were performed excluding pre-term births, small for gestational age (SGA), and pre-pregnancy hypertension and depression. There was a significant association between HDP and a twofold increased risk of ASD (AOR = 2.10 [95% CI 1.20–3.70]). Excluding preterm births, SGA births, and offspring of women who had pre-pregnancy hypertension or over the age of 40 did not change the results materially. At the cellular level, exposure of foetal cortical neurons to 3% serum isolated from women with an established HDP increased neuronal growth and branching in vitro. These findings indicate that HDP exposure may increase the risk of ASD in the offspring.en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationCurran, E. A., O’Keeffe, G. W., Looney, A. M., Moloney, G., Hegarty, S. V., Murray, D. M., Khashan, A. S. and Kenny, L. C. (2017) ‘Exposure to hypertensive disorders of pregnancy increases the risk of autism spectrum disorder in affected offspring’, Molecular Neurobiology, 55, pp. 5557–5564. doi:10.1007/s12035-017-0794-xen
dc.identifier.doi10.1007/s12035-017-0794-x
dc.identifier.endpage5564
dc.identifier.issn1559-1182
dc.identifier.issn0893-7648
dc.identifier.journaltitleMolecular Neurobiologyen
dc.identifier.startpage5557
dc.identifier.urihttps://hdl.handle.net/10468/5344
dc.identifier.volume55
dc.language.isoenen
dc.publisherSpringer International Publishing AGen
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2272/IE/Irish Centre for Fetal and Neonatal Translational Research (INFANT)/en
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Career Development Award/15/CDA/3498/IE/Development of GDF5 neurotrophic factor therapy for Parkinson_s disease./en
dc.rights© 2017, Springer Science+Business Media, LLC. This is a post-peer-review, pre-copyedit version of an article published in Molecular Neurobiology. The final authenticated version is available online at: http://dx.doi.org/10.1007/s12035-017-0794-xen
dc.subjectAutism spectrum disorderen
dc.subjectASDen
dc.subjectAutismen
dc.subjectPre-eclampsiaen
dc.subjectPregnancyen
dc.subjectHypertensive disordersen
dc.titleExposure to hypertensive disorders of pregnancy increases the risk of autism spectrum disorder in affected offspringen
dc.typeArticle (peer-reviewed)en
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