Food for thought: The role of nutrition in the microbiota-gut–brain axis

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dc.contributor.authorOriach, Clara Seira
dc.contributor.authorRobertson, Ruairi C.
dc.contributor.authorStanton, Catherine
dc.contributor.authorCryan, John F.
dc.contributor.authorDinan, Timothy G.
dc.contributor.funderScience Foundation Irelanden
dc.contributor.funderHealth Research Boarden
dc.contributor.funderMarine Instituteen
dc.contributor.funderTeagascen
dc.contributor.funderEnterprise Irelanden
dc.contributor.funderDepartment of Agriculture, Food and the Marineen
dc.date.accessioned2017-04-11T15:44:31Z
dc.date.available2017-04-11T15:44:31Z
dc.date.issued2016-01-21
dc.date.updated2017-04-11T15:29:26Z
dc.description.abstractRecent research has provided strong evidence for the role of the commensal gut microbiota in brain function and behaviour. Many potential pathways are involved in this bidirectional communication between the gut microbiota and the brain such as immune mechanisms, the vagus nerve and microbial neurometabolite production. Dysbiosis of gut microbial function has been associated with behavioural and neurophysical deficits, therefore research focused on developing novel therapeutic strategies to treat psychiatric disorders by targeting the gut microbiota is rapidly growing. Numerous factors can influence the gut microbiota composition such as health status, mode of birth delivery and genetics, but diet is considered among the most crucial factors impacting on the human gut microbiota from infancy to old age. Thus, dietary interventions may have the potential to modulate psychiatric symptoms associated with gut–brain axis dysfunction. Further clinical and in vivo studies are needed to better understand the mechanisms underlying the link between nutrition, gut microbiota and control of behaviour and mental health.en
dc.description.sponsorshipScience Foundation Ireland (centre grant, APC Microbiome Institute grant number SFI/12/RC/2273); Health Research Board, Ireland (Grant Numbers HRA_POR/2011/23 and HRA_POR/2012/32); Marine Institute (Sea Change Strategy); Teagasc (NutraMara programme (Grant-Aid Agreement No. MFFRI/07/01)); Enterprise Ireland (SMART FOOD project: ‘Science Based ‘Intelligent’/Functional and Medical Foods for Optimum Brain Health, Targeting Depression and Cognition’ project (Ref No. 13/F/411) with the support of the Marine Institute and the Department of Agriculture, Food and the Marine (DAFM) in Ireland)en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationOriach, C. S., Robertson, R. C., Stanton, C., Cryan, J. F. and Dinan, T. G. (2016) 'Food for thought: The role of nutrition in the microbiota-gut–brain axis', Clinical Nutrition Experimental, 6, pp. 25-38. doi:10.1016/j.yclnex.2016.01.003en
dc.identifier.doi10.1016/j.yclnex.2016.01.003
dc.identifier.endpage38en
dc.identifier.issn2352-9393
dc.identifier.journaltitleClinical Nutrition Experimentalen
dc.identifier.startpage25en
dc.identifier.urihttps://hdl.handle.net/10468/3876
dc.identifier.volume6en
dc.language.isoenen
dc.publisherElsevier Ltd on behalf of European Society for Clinical Nutrition and Metabolismen
dc.rights© 2016 The Authors. Published by Elsevier Ltd on behalf of European Society for Clinical Nutrition and Metabolism. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).en
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectDieten
dc.subjectPsychobioticsen
dc.subjectGut microbiotaen
dc.subjectPsychiatric disordersen
dc.subjectGut-brain axisen
dc.titleFood for thought: The role of nutrition in the microbiota-gut–brain axisen
dc.typeArticle (peer-reviewed)en
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