Volatility as a concept to understand the impact of stress on the microbiome

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dc.contributor.authorBastiaanssen, Thomaz F. S.
dc.contributor.authorGururajan, Anand
dc.contributor.authorvan de Wouw, Marcel
dc.contributor.authorMoloney, Gerard M.
dc.contributor.authorRitz, Nathaniel L.
dc.contributor.authorLong-Smith, Caitriona M.
dc.contributor.authorWiley, Niamh
dc.contributor.authorMurphy, Amy
dc.contributor.authorLyte, Joshua M.
dc.contributor.authorFouhy, Fiona
dc.contributor.authorStanton, Catherine
dc.contributor.authorClaesson, Marcus J.
dc.contributor.authorDinan, Timothy G.
dc.contributor.authorCryan, John F.
dc.contributor.funderEuropean Research Councilen
dc.contributor.funderScience Foundation Irelanden
dc.contributor.funderDepartment of Agriculture, Food and the Marine, Irelanden
dc.contributor.funderHealth Research Boarden
dc.date.accessioned2022-04-05T14:30:40Z
dc.date.available2022-04-05T14:30:40Z
dc.date.issued2021-02
dc.date.updated2022-04-05T14:09:09Z
dc.description.abstractThe microbiome-gut-brain-axis is a complex phenomenon spanning several dynamic systems in the body which can be parsed at a molecular, cellular, physiological and ecological level. A growing body of evidence indicates that this axis is particularly sensitive to the effects of stress and that it may be relevant to stress resilience and susceptibility. Although stress-induced changes in the composition of the microbiome have been reported, the degree of compositional change over time, which we define as volatility, has not been the subject of in-depth scrutiny. Using a chronic psychosocial stress paradigm in male mice, we report that the volatility of the microbiome significantly correlated with several readouts of the stress response, including behaviour and corticosterone response. We then validated these findings in a second independent group of stressed mice. Additionally, we assessed the relationship between volatility and stress parameters in a cohort of health volunteers who were undergoing academic exams and report similar observations. Finally, we found inter-species similarities in the microbiome stress response on a functional level. Our research highlights the effects of stress on the dynamic microbiome and underscores the informative value of volatility as a parameter that should be considered in all future analyses of the microbiome.en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid105047en
dc.identifier.citationBastiaanssen, T. F. S., Gururajan, A., van de Wouw, M., Moloney, G. M., Ritz, N. L., Long-Smith, C. M., Wiley, N., Murphy, A., Lyte, J. M., Fouhy, F., Stanton, C., Claesson, M. J., Dinan, T. G. and Cryan, J. F. (2021) 'Volatility as a concept to understand the impact of stress on the microbiome', Psychoneuroendocrinology, 124, 105047 (13pp). doi: 10.1016/j.psyneuen.2020.105047en
dc.identifier.doi10.1016/j.psyneuen.2020.105047en
dc.identifier.endpage13en
dc.identifier.issn0306-4530
dc.identifier.journaltitlePsychoneuroendocrinologyen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/13033
dc.identifier.volume124en
dc.language.isoenen
dc.publisherElsevieren
dc.relation.projectinfo:eu-repo/grantAgreement/EC/H2020::MSCA-IF-EF-ST/704995/EU/Decoding Stress Resilience/DE-STRESSen
dc.relation.projectinfo:eu-repo/grantAgreement/EC/FP7::SP1::KBBE/613979/EU/Microbiome Influence on Energy balance and Brain Development-Function Put into Action to Tackle Diet-related Diseases and Behavior./MYNEWGUTen
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/en
dc.rights© 2020 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectChronic stressen
dc.subjectMicrobiomeen
dc.subjectGut-brain axisen
dc.subjectVolatilityen
dc.subjectCorticosteroneen
dc.titleVolatility as a concept to understand the impact of stress on the microbiomeen
dc.typeArticle (peer-reviewed)en
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