Intervention strategies for cesarean section-induced alterations in the microbiota-gut-brain axis

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dc.contributor.authorMoya-PĂ©rez, Angela
dc.contributor.authorLuczynski, Pauline
dc.contributor.authorRenes, Ingrid B.
dc.contributor.authorWang, Shugui
dc.contributor.authorBorre, Yuliya E.
dc.contributor.authorRyan, C. Anthony
dc.contributor.authorKnol, Jan
dc.contributor.authorStanton, Catherine
dc.contributor.authorDinan, Timothy G.
dc.contributor.authorCryan, John F.
dc.contributor.funderDepartment of Agriculture, Food and the Marine
dc.contributor.funderSeventh Framework Programme
dc.contributor.funderScience Foundation Ireland
dc.date.accessioned2018-06-15T11:47:19Z
dc.date.available2018-06-15T11:47:19Z
dc.date.issued2017
dc.description.abstractMicrobial colonization of the gastrointestinal tract is an essential process that modulates host physiology and immunity. Recently, researchers have begun to understand how and when these microorganisms colonize the gut and the early-life factors that impact their natural ecological establishment. The vertical transmission of maternal microbes to the offspring is a critical factor for host immune and metabolic development. Increasing evidence also points to a role in the wiring of the gut-brain axis. This process may be altered by various factors such as mode of delivery, gestational age at birth, the use of antibiotics in early life, infant feeding, and hygiene practices. In fac(t), these early exposures that impact the intestinal microbiota have been associated with the development of diseases such as obesity, type 1 diabetes, asthma, allergies, and even neurodevelopmental disorders. The present review summarizes the impact of cesarean birth on the gut microbiome and the health status of the developing infant and discusses possible preventative and restorative strategies to compensate for early-life microbial perturbations.en
dc.description.sponsorshipIrish Department of Agriculture Food Marine (INFANTMET; SMARTFOOD; TODDLERFOOD)en
dc.description.statusPeer reviewed
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationMoya-Pérez, A., Luczynski, P., Renes, I. B., Wang, S., Borre, Y., Anthony Ryan, C., Knol, J., Stanton, C., Dinan, T. G. and Cryan, J. F. (2017) 'Intervention strategies for cesarean section–induced alterations in the microbiota-gut-brain axis', Nutrition Reviews, 75(4), pp. 225-240. doi: 10.1093/nutrit/nuw069en
dc.identifier.doi10.1093/nutrit/nuw069
dc.identifier.endpage240
dc.identifier.issn0029-6643
dc.identifier.issued4
dc.identifier.journaltitleNutrition Reviewsen
dc.identifier.startpage225
dc.identifier.urihttps://hdl.handle.net/10468/6355
dc.identifier.volume75
dc.language.isoenen
dc.publisherOxford University Pressen
dc.relation.projectinfo:eu-repo/grantAgreement/EC/FP7::SP1::KBBE/613979/EU/Microbiome Influence on Energy balance and Brain Development-Function Put into Action to Tackle Diet-related Diseases and Behavior./MYNEWGUT
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/
dc.relation.urihttps://academic.oup.com/nutritionreviews/article/75/4/225/3098294
dc.rights© 2017, the Authors. Published by Oxford University Press on behalf of the International Life Sciences Institute. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work properly cited. For commercial re-use, please contact journals.permissions@oup.comen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectCesarean sectionen
dc.subjectMetabolismen
dc.subjectMicrobiotaen
dc.subjectImmunityen
dc.subjectPrebioticsen
dc.subjectProbioticsen
dc.titleIntervention strategies for cesarean section-induced alterations in the microbiota-gut-brain axisen
dc.typeArticle (peer-reviewed)en
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