Exploring the ecological effects of naturally antibiotic-insensitive Bifidobacteria in the recovery of the resilience of the gut microbiota during and after antibiotic treatment

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dc.contributor.authorArgentini, C.
dc.contributor.authorMancabelli, L.
dc.contributor.authorAlessandri, G.
dc.contributor.authorTarracchini, C.
dc.contributor.authorBarbetti, M.
dc.contributor.authorCarnevali, L.
dc.contributor.authorLonghi, G.
dc.contributor.authorViappiani, A.
dc.contributor.authorAnzalone, R.
dc.contributor.authorMilani, C.
dc.contributor.authorSgoifo, A.
dc.contributor.authorvan Sinderen, Douwe
dc.contributor.authorVentura, M.
dc.contributor.authorTurroni, F.
dc.contributor.funderMinistero della Saluteen
dc.contributor.funderProgramma Operativo Nazionale Ricerca e Competitivitàen
dc.contributor.funderScience Foundation Irelanden
dc.contributor.funderFondazione Cariparmaen
dc.date.accessioned2022-09-28T15:42:53Z
dc.date.available2022-09-28T15:42:53Z
dc.date.issued2022-06-02
dc.date.updated2022-09-28T15:31:40Z
dc.description.abstractAmoxicillin-clavulanic acid (AMC) is the most widely used antibiotic, being frequently prescribed to infants. Particular members of the genus Bifidobacterium are among the first microbial colonizers of the infant gut, and it has been demonstrated that they exhibit various activities beneficial for their human host, including promotion/maintenance of the human gut microbiota homeostasis. It has been shown that natural resistance of bifidobacteria to AMC is limited to a small number of strains. In the current study, we investigated the mitigation effects of AMC-resistant bifidobacteria in diversity preservation of the gut microbiota during AMC treatment. To this end, an in vitro coculture experiment based on infant fecal samples and an in vivo study employing a rodent model were performed. The results confirmed the ability of AMC-resistant bifidobacterial strains to bolster gut microbiota resilience, while specific covariance analysis revealed strain-specific and variable impacts on the microbiota composition by individual bifidobacterial taxa. IMPORTANCE The first microbial colonizers of the infant gut are members of the genus Bifidobacterium, which exhibit different activities beneficial to their host. Amoxicillin-clavulanic acid (AMC) is the most frequently prescribed antibiotic during infancy, and few strains of bifidobacteria are known to show a natural resistance to this antibiotic. In the present work, we evaluated the possible positive effects of AMC-resistant bifidobacterial strains in maintaining gut microbiota diversity during AMC exposure, performing an in vitro and in vivo experiment based on an infant gut model and a rodent model, respectively. Our results suggested the ability of AMC-resistant bifidobacterial strains to support gut microbiota restoration.en
dc.description.sponsorshipProgramma Operativo Nazionale Ricerca e Innovazione 2014-2020 ((PON R&I 2014-2020) (project ARS01_00530)); Progetto Ricerca Finalizzata 2018, Ministero della Salute (RF GR-2018-12365988); Science Foundation Ireland (APC Microbiome Ireland funded by Science Foundation Ireland (SFI), through the Irish Government’s National Development Plan (grants SFI/12/RC/2273-P1 and SFI/12/RC/2273-P2)); Fondazione Cariparma, Parma, Italyen
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleide00522-22en
dc.identifier.citationArgentini, C., Mancabelli, L., Alessandri, G., Tarracchini, C., Barbetti, M., Carnevali, L., Longhi, G., Viappiani, A., Anzalone, R., Milani, C., Sgoifo, A., van Sinderen, D., Ventura, M. and Turroni, F. (2022) ‘Exploring the ecological effects of naturally antibiotic-insensitive bifidobacteria in the recovery of the resilience of the gut microbiota during and after antibiotic treatment’, Applied and Environmental Microbiology, 88(12), e00522-22 (11 pp). doi: 10.1128/aem.00522-22.en
dc.identifier.doi10.1128/aem.00522-22en
dc.identifier.endpage11en
dc.identifier.issn1098-5336
dc.identifier.issued12en
dc.identifier.journaltitleApplied and Environmental Microbiologyen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/13695
dc.identifier.volume88en
dc.language.isoenen
dc.publisherAmerican Society for Microbiologyen
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/en
dc.relation.urihttps://doi.org/10.1128/aem.00522-22
dc.rights© 2022 American Society for Microbiology. All Rights Reserveden
dc.subjectBifidobacteriumen
dc.subjectGut microbiotaen
dc.subjectAntibioticen
dc.titleExploring the ecological effects of naturally antibiotic-insensitive Bifidobacteria in the recovery of the resilience of the gut microbiota during and after antibiotic treatmenten
dc.typeArticle (peer-reviewed)en
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