Interaction between caffeine and polymorphisms of glutamate ionotropic receptor NMDA type subunit 2A (GRIN2A) and cytochrome P450 1A2 (CYP1A2) on Parkinson's disease risk

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dc.contributor.authorKim, Iris Y.en
dc.contributor.authorO'Reilly, Éilis J.en
dc.contributor.authorHughes, Katherine C.en
dc.contributor.authorGao, Xiangen
dc.contributor.authorSchwarzschild, Michael A.en
dc.contributor.authorMcCullough, Marjorie L.en
dc.contributor.authorHannan, Marian T.en
dc.contributor.authorBetensky, Rebecca A.en
dc.contributor.authorAscherio, Albertoen
dc.contributor.funderU.S. Department of Defenseen
dc.contributor.funderNational Institutes of Healthen
dc.date.accessioned2024-07-16T10:41:31Z
dc.date.available2024-07-16T10:41:31Z
dc.date.issued2018-03-05en
dc.description.abstractBackground: Caffeine intake has been inversely associated with Parkinson's disease (PD) risk. This relationship may be modified by polymorphisms of glutamate ionotropic receptor NMDA type subunit 2A (GRIN2A) and cytochrome P450 1A2 (CYP1A2), but the results of previous studies have been inconsistent. Method: We examined the interaction of caffeine intake with GRIN2A-rs4998386 and CYP1A2-rs762551 polymorphisms in influencing PD risk among 829 incident cases of PD and 2,754 matched controls selected among participants in the following 3 large prospective ongoing cohorts: the Nurses' Health Study, the Health Professionals' Follow-up Study, and the Cancer Prevention Study II Nutrition Cohort. Matching factors included cohort, birth year, source of DNA, date of DNA collection, and race. Relative risks and 95% confidence intervals were estimated using conditional logistic models. Interactions were tested both on the multiplicative scale and on the additive scale. Results: Overall, caffeine intake was associated with a lower PD risk (adjusted relative risk for highest versus lowest tertile = 0.70; 95% confidence interval, 0.57-0.86; p < .001). In analyses stratified by the GRIN2A-rs4998386 genotype, the multivariable-adjusted relative risk of PD comparing the highest to the lowest tertile of caffeine was 0.69 (95% confidence interval, 0.55-0.88; p < .01) among individuals homozygous for the C allele, and 0.85 (95% confidence interval, 0.55-1.32; p = .47; pRERI = .43) among carriers for the T allele. Interactions between caffeine and GRIN2A were not significant in either the multiplicative or additive scales. We also did not observe significant interactions for CYP1A2-rs762551 and incident PD risk. Conclusion: Our findings do not support the hypothesis of an interaction between the GRIN2A-rs4998386 or CYP1A2-rs762551 polymorphism and caffeine intake in determining PD risk. © 2018 International Parkinson and Movement Disorder Societyen
dc.description.sponsorshipNational Institutes of Health (Grants UM1 CA186107; UM1 CA167552); U.S. Department of Defense (Grant W81XWH-14-0131)en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationKim, I. Y., O'Reilly, É. J., Hughes, K. C., Gao, X., Schwarzschild, M. A., McCullough, M. L., Hannan, M. T., Betensky, R. A. and Ascherio, A. (2018) 'Interaction between caffeine and polymorphisms of glutamate ionotropic receptor NMDA type subunit 2A (GRIN2A) and cytochrome P450 1A2 (CYP1A2) on Parkinson's disease risk', Movement Disorders, 33(3), pp. 414-420. https://doi.org/10.1002/mds.27279en
dc.identifier.doihttps://doi.org/10.1002/mds.27279en
dc.identifier.eissn1531-8257en
dc.identifier.endpage420en
dc.identifier.issn0885-3185en
dc.identifier.issued3en
dc.identifier.journaltitleMovement Disordersen
dc.identifier.startpage414en
dc.identifier.urihttps://hdl.handle.net/10468/16131
dc.identifier.volume33en
dc.language.isoenen
dc.publisherJohn Wiley & Sons, Inc.en
dc.relation.projectCA167552en
dc.rights© 2018 International Parkinson and Movement Disorder Society. John Wiley & Sons Ltd. This is the accepted version of the following item: Kim, I. Y., O'Reilly, É. J., Hughes, K. C., Gao, X., Schwarzschild, M. A., McCullough, M. L., Hannan, M. T., Betensky, R. A. and Ascherio, A. (2018) 'Interaction between caffeine and polymorphisms of glutamate ionotropic receptor NMDA type subunit 2A (GRIN2A) and cytochrome P450 1A2 (CYP1A2) on Parkinson's disease risk', Movement Disorders, 33(3), pp. 414-420, which has been published in final form at: h https://doi.org/10.1002/mds.27279. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.en
dc.subjectCaffeineen
dc.subjectParkinson's disease (PD)en
dc.subjectGRIN2Aen
dc.subjectInteractionen
dc.subjectCYP1A2en
dc.titleInteraction between caffeine and polymorphisms of glutamate ionotropic receptor NMDA type subunit 2A (GRIN2A) and cytochrome P450 1A2 (CYP1A2) on Parkinson's disease risken
dc.typeArticle (peer-reviewed)en
oaire.citation.issue3en
oaire.citation.volume33en
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