The neuroendocrinology of the microbiota-gut-brain axis: a behavioural perspective

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dc.contributor.authorCussotto, Sofia
dc.contributor.authorSandhu, Kiran V.
dc.contributor.authorDinan, Timothy G.
dc.contributor.authorCryan, John F.
dc.contributor.funderScience Foundation Irelanden
dc.contributor.funderHealth Research Boarden
dc.contributor.funderSeventh Framework Programmeen
dc.date.accessioned2018-05-24T11:32:25Z
dc.date.available2018-05-24T11:32:25Z
dc.date.issued2018-05-10
dc.date.updated2018-05-24T11:21:30Z
dc.description.abstractThe human gut harbours trillions of symbiotic bacteria that play a key role in programming different aspects of host physiology in health and disease. These intestinal microbes are also key components of the gut-brain axis, the bidirectional communication pathway between the gut and the central nervous system (CNS). In addition, the CNS is closely interconnected with the endocrine system to regulate many physiological processes. An expanding body of evidence is supporting the notion that gut microbiota modifications and/or manipulations may also play a crucial role in the manifestation of specific behavioural responses regulated by neuroendocrine pathways. In this review, we will focus on how the intestinal microorganisms interact with elements of the host neuroendocrine system to modify behaviours relevant to stress, eating behaviour, sexual behaviour, social behaviour, cognition and addiction.en
dc.description.sponsorshipScience Foundation Ireland (APC Microbiome Ireland research centre funded by Science Foundation Ireland (SFI), through the Irish Government’s National Development Plan); Health Research Board (HRA_POR/2011/23, HRA_POR/2012/32);en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationCussotto, S., Sandhu, K. V., Dinan, T. G. and Cryan, J. F. (2018) 'The Neuroendocrinology of the Microbiota-Gut-Brain Axis: A Behavioural Perspective', Frontiers in Neuroendocrinology, In Press. doi: 10.1016/j.yfrne.2018.04.002en
dc.identifier.doi10.1016/j.yfrne.2018.04.002
dc.identifier.endpage74en
dc.identifier.issn0091-3022
dc.identifier.journaltitleFrontiers In Neuroendocrinologyen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/6186
dc.language.isoenen
dc.publisherElsevieren
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/en
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Centre for Science Engineering and Technology (CSET)/07/CE/B1368/IE/CSET APC: Alimentary Pharmabiotic Centre - Second Term Funding/en
dc.relation.projectinfo:eu-repo/grantAgreement/EC/FP7::SP1::HEALTH/201714/EU/Serotonin and GABA-B receptors in anxiety : from developmental risk factors to treatment./DEVANXen
dc.relation.urihttp://www.sciencedirect.com/science/article/pii/S0091302218300396
dc.rights© 2018 Elsevier Inc. All rights reserved. This manuscript version is made available under the CC-BY-NC-ND 4.0 licenseen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectNeuroendocrine systemen
dc.subjectHormonesen
dc.subjectCorticosteroneen
dc.subjectStressen
dc.subjectHPA axisen
dc.subjectEating behaviouren
dc.subjectSexual behaviouren
dc.subjectSocial behaviouren
dc.subjectLearningen
dc.subjectAddictionen
dc.titleThe neuroendocrinology of the microbiota-gut-brain axis: a behavioural perspectiveen
dc.typeArticle (peer-reviewed)en
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