The neuroendocrinology of the microbiota-gut-brain axis: a behavioural perspective
dc.contributor.author | Cussotto, Sofia | |
dc.contributor.author | Sandhu, Kiran V. | |
dc.contributor.author | Dinan, Timothy G. | |
dc.contributor.author | Cryan, John F. | |
dc.contributor.funder | Science Foundation Ireland | en |
dc.contributor.funder | Health Research Board | en |
dc.contributor.funder | Seventh Framework Programme | en |
dc.date.accessioned | 2018-05-24T11:32:25Z | |
dc.date.available | 2018-05-24T11:32:25Z | |
dc.date.issued | 2018-05-10 | |
dc.date.updated | 2018-05-24T11:21:30Z | |
dc.description.abstract | The human gut harbours trillions of symbiotic bacteria that play a key role in programming different aspects of host physiology in health and disease. These intestinal microbes are also key components of the gut-brain axis, the bidirectional communication pathway between the gut and the central nervous system (CNS). In addition, the CNS is closely interconnected with the endocrine system to regulate many physiological processes. An expanding body of evidence is supporting the notion that gut microbiota modifications and/or manipulations may also play a crucial role in the manifestation of specific behavioural responses regulated by neuroendocrine pathways. In this review, we will focus on how the intestinal microorganisms interact with elements of the host neuroendocrine system to modify behaviours relevant to stress, eating behaviour, sexual behaviour, social behaviour, cognition and addiction. | en |
dc.description.sponsorship | Science Foundation Ireland (APC Microbiome Ireland research centre funded by Science Foundation Ireland (SFI), through the Irish Government’s National Development Plan); Health Research Board (HRA_POR/2011/23, HRA_POR/2012/32); | en |
dc.description.status | Peer reviewed | en |
dc.description.version | Accepted Version | en |
dc.format.mimetype | application/pdf | en |
dc.identifier.citation | Cussotto, S., Sandhu, K. V., Dinan, T. G. and Cryan, J. F. (2018) 'The Neuroendocrinology of the Microbiota-Gut-Brain Axis: A Behavioural Perspective', Frontiers in Neuroendocrinology, In Press. doi: 10.1016/j.yfrne.2018.04.002 | en |
dc.identifier.doi | 10.1016/j.yfrne.2018.04.002 | |
dc.identifier.endpage | 74 | en |
dc.identifier.issn | 0091-3022 | |
dc.identifier.journaltitle | Frontiers In Neuroendocrinology | en |
dc.identifier.startpage | 1 | en |
dc.identifier.uri | https://hdl.handle.net/10468/6186 | |
dc.language.iso | en | en |
dc.publisher | Elsevier | en |
dc.relation.project | info:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/ | en |
dc.relation.project | info:eu-repo/grantAgreement/SFI/SFI Centre for Science Engineering and Technology (CSET)/07/CE/B1368/IE/CSET APC: Alimentary Pharmabiotic Centre - Second Term Funding/ | en |
dc.relation.project | info:eu-repo/grantAgreement/EC/FP7::SP1::HEALTH/201714/EU/Serotonin and GABA-B receptors in anxiety : from developmental risk factors to treatment./DEVANX | en |
dc.relation.uri | http://www.sciencedirect.com/science/article/pii/S0091302218300396 | |
dc.rights | © 2018 Elsevier Inc. All rights reserved. This manuscript version is made available under the CC-BY-NC-ND 4.0 license | en |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | en |
dc.subject | Neuroendocrine system | en |
dc.subject | Hormones | en |
dc.subject | Corticosterone | en |
dc.subject | Stress | en |
dc.subject | HPA axis | en |
dc.subject | Eating behaviour | en |
dc.subject | Sexual behaviour | en |
dc.subject | Social behaviour | en |
dc.subject | Learning | en |
dc.subject | Addiction | en |
dc.title | The neuroendocrinology of the microbiota-gut-brain axis: a behavioural perspective | en |
dc.type | Article (peer-reviewed) | en |