Dose-response efficacy and mechanisms of orally administered CLA-producing Bifidobacterium breve CCFM683 on DSS-induced colitis in mice

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dc.contributor.authorChen, Yang
dc.contributor.authorJin, Yan
dc.contributor.authorStanton, Catherine
dc.contributor.authorRoss, R. Paul
dc.contributor.authorWang, Zhi
dc.contributor.authorZhao, Jianxin
dc.contributor.authorZhang, Hao
dc.contributor.authorYang, Bo
dc.contributor.authorChen, Wei
dc.contributor.funderNational Natural Science Foundation of Chinaen
dc.contributor.funderNational First-Class Discipline Program of Food Science and Technologyen
dc.contributor.funderFundamental Research Funds for the Central Universitiesen
dc.contributor.funderPostgraduate Research & Practice Innovation Program of Jiangsu Provinceen
dc.contributor.funderWuxi Young Talent Foundationen
dc.contributor.funderCollaborative Innovationcenter of Food Safety and Quality Control in Jiangsu Provinceen
dc.date.accessioned2023-03-15T16:06:40Z
dc.date.available2023-03-15T16:06:40Z
dc.date.issued2020-12
dc.date.updated2023-03-15T15:19:47Z
dc.description.abstractThis study designed to explore the dose-effect relationship of CCFM683 in relieving colitis and investigate the mechanisms involved. Specifically, the concentration of mucin2, goblet cells and tight junction proteins were significantly up-regulated by 1010 and 109 cfu/day CCFM683. Moreover, interleukin (IL)-1 beta and IL-6 were significantly down-regulated by 1010 and 109 cfu/day CCFM683. Furthermore, gut microbiota in mice treated with 1010 and 109 cfu/day CCFM683 were rebalanced via improving the unbalanced interaction, regulating the diversity, increasing Bifidobacterium and decreasing Bacteroides and Sutterella. Moreover, the colonic conjugated linoleic acid (CLA) concentration was significantly positive correlated with the effectiveness of the strain in relieving colitis. The gavage dose of CCFM683 should be more than 108.65 cfu/day in mice for improving colitis according to dose-effect curve. In conclusion, CCFM683 supplementation alleviated colitis in a dose-dependent manner by improving intestinal epithelial barriers, protecting the intestinal mucus layer, restoring gut micro biota, and down-regulating the inflammatory cytokines.en
dc.description.sponsorshipNational Natural Science Foundation of China (Nos. 32072227, 31801521, 31820103010, 31530056); National First-Class Discipline Program of Food Science and Technology (JUFSTR20180102); Fundamental Research Funds for the Central Universities ((JUSRP52003B); Postgraduate Research & Practice Innovation Program of Jiangsu Province ((KYCX19_1829); Wuxi Young Talent Foundation (QNRC075)en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid104245en
dc.identifier.citationChen, Y., Jin, Y., Stanton, C., Ross, R.P., Wang, Z., Zhao, J., Zhang, H., Yang, B. and Chen, W. (2020) ‘Dose-response efficacy and mechanisms of orally administered CLA-producing Bifidobacterium breve CCFM683 on DSS-induced colitis in mice’, Journal of Functional Foods, 75, 104245 (17pp). doi: 10.1016/j.jff.2020.104245en
dc.identifier.doi10.1016/j.jff.2020.104245en
dc.identifier.endpage17en
dc.identifier.issn1756-4646
dc.identifier.journaltitleJournal Of Functional Foodsen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/14314
dc.identifier.volume75en
dc.language.isoenen
dc.publisherElsevieren
dc.rights© 2020 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)en
dc.rights.uri(http://creativecommons.org/licenses/by-nc-nd/4.0/)en
dc.subjectEpithelial barrier functionen
dc.subjectInflammatory-bowel-diseaseen
dc.subjectInduced ulcerative-colitisen
dc.subjectGut microbiotaen
dc.subjectMetabolismen
dc.subjectProbioticsen
dc.subjectTighten
dc.subjectCooccurrenceen
dc.subjectJunctionsen
dc.subjectCellsen
dc.titleDose-response efficacy and mechanisms of orally administered CLA-producing Bifidobacterium breve CCFM683 on DSS-induced colitis in miceen
dc.typeArticle (peer-reviewed)en
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