Systematic review of vitamin D and hypertensive disorders of pregnancy

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dc.contributor.authorO'Callaghan, Karen M.
dc.contributor.authorKiely, Mairead E.
dc.contributor.funderSeventh Framework Programme
dc.date.accessioned2018-05-02T10:16:27Z
dc.date.available2018-05-02T10:16:27Z
dc.date.issued2018
dc.description.abstractThis narrative systematic review evaluates growing evidence of an association between low maternal vitamin D status and increased risk of hypertensive disorders. The inclusion of interventional, observational, and dietary studies on vitamin D and all hypertensive disorders of pregnancy is a novel aspect of this review, providing a unique contribution to an intensively-researched area that still lacks a definitive conclusion. To date, trial evidence supports a protective effect of combined vitamin D and calcium supplementation against preeclampsia. Conflicting data for an association of vitamin D with gestational hypertensive disorders in observational studies arises from a number of sources, including large heterogeneity between study designs, lack of adherence to standardized perinatal outcome definitions, variable quality of analytical data for 25-hydroxyvitamin D (25(OH)D), and inconsistent data reporting of vitamin D status. While evidence does appear to lean towards an increased risk of gestational hypertensive disorders at 25(OH)D concentrations <50 nmol/L, caution should be exercised with dosing in trials, given the lack of data on long-term safety. The possibility that a fairly narrow target range for circulating 25(OH)D for achievement of clinically-relevant improvements requires further exploration. As hypertension alone, and not preeclampsia specifically, limits intrauterine growth, evaluation of the relationship between vitamin D status and all terms of hypertension in pregnancy is a clinically relevant area for research and should be prioritised in future randomised trials.en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid294
dc.identifier.citationO’Callaghan, K. and Kiely, M. (2018) 'Systematic review of vitamin D and hypertensive disorders of pregnancy', Nutrients, 10(3), 294 (18pp). doi: 10.3390/nu10030294en
dc.identifier.doi10.3390/nu10030294
dc.identifier.endpage18
dc.identifier.issn2072-6643
dc.identifier.issued3
dc.identifier.journaltitleNutrientsen
dc.identifier.startpage1
dc.identifier.urihttps://hdl.handle.net/10468/5949
dc.identifier.volume10
dc.language.isoenen
dc.publisherMDPI AGen
dc.relation.projectinfo:eu-repo/grantAgreement/EC/FP7::SP1::KBBE/613977/EU/Food-based solutions for Optimal vitamin D Nutrition and health through the life cycle/ODIN
dc.relation.urihttp://www.mdpi.com/2072-6643/10/3/294
dc.rights© 2018, the Authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject25-hydroxyvitamin Den
dc.subjectGestational hypertensionen
dc.subjectPreeclampsiaen
dc.subjectVitamin Den
dc.titleSystematic review of vitamin D and hypertensive disorders of pregnancyen
dc.typeArticle (peer-reviewed)en
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