You've got male: Sex and the microbiota-gut-brain axis across the lifespan

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dc.contributor.authorJaggar, Minal
dc.contributor.authorRea, Kieran
dc.contributor.authorSpichak, Simon
dc.contributor.authorDinan, Timothy G.
dc.contributor.authorCryan, John F.
dc.contributor.funderScience Foundation Irelanden
dc.date.accessioned2020-02-24T09:55:30Z
dc.date.available2020-02-24T09:55:30Z
dc.date.issued2019-12-02
dc.date.updated2020-02-24T09:47:10Z
dc.description.abstractSex is a critical factor in the diagnosis and development of a number of mental health disorders including autism, schizophrenia, depression, anxiety, Parkinson's disease, multiple sclerosis, anorexia nervosa and others; likely due to differences in sex steroid hormones and genetics. Recent evidence suggests that sex can also influence the complexity and diversity of microbes that we harbour in our gut; and reciprocally that our gut microbes can directly and indirectly influence sex steroid hormones and central gene activation. There is a growing emphasis on the role of gastrointestinal microbiota in the maintenance of mental health and their role in the pathogenesis of disease. In this review, we introduce mechanisms by which gastrointestinal microbiota are thought to mediate positive health benefits along the gut-brain axis, we report how they may be modulated by sex, the role they play in sex steroid hormone regulation, and their sex-specific effects in various disorders relating to mental health.en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid100815en
dc.identifier.citationJaggar, M., Rea, K., Spichak, S., Dinan, T. G. and Cryan, J. F. (2020) 'You've got male: Sex and the microbiota-gut-brain axis across the lifespan', Frontiers in Neuroendocrinology, 56, 100815 (22pp). doi: 10.1016/j.yfrne.2019.100815en
dc.identifier.doi10.1016/j.yfrne.2019.100815en
dc.identifier.eissn1095-6808
dc.identifier.endpage22en
dc.identifier.issn0091-3022
dc.identifier.journaltitleFrontiers in Neuroendocrinologyen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/9689
dc.identifier.volume56en
dc.language.isoenen
dc.publisherElsevier Inc.en
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/en
dc.relation.urihttp://www.sciencedirect.com/science/article/pii/S0091302218301298
dc.rights© 2019, Elsevier Inc. All rights reserved. This manuscript version is made available under the CC BY-NC-ND 4.0 license.en
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectMicrobiota-gut-brain axisen
dc.subjectMicrobiomeen
dc.subjectSex differenceen
dc.subjectMental disordersen
dc.subjectAntibioticen
dc.subjectNeurological disordersen
dc.subjectGerm-freeen
dc.titleYou've got male: Sex and the microbiota-gut-brain axis across the lifespanen
dc.typeArticle (peer-reviewed)en
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