Beneficial bile acid metabolism from Lactobacillus plantarum of food origin
| dc.contributor.author | Prete, Roberta | |
| dc.contributor.author | Long, Sarah Louise | |
| dc.contributor.author | Lopez Gallardo, Alvaro | |
| dc.contributor.author | Gahan, Cormac G. | |
| dc.contributor.author | Corsetti, Aldo | |
| dc.contributor.author | Joyce, Susan A. | |
| dc.contributor.funder | Science Foundation Ireland | en |
| dc.contributor.funder | Ministero dell’Istruzione, dell’Università e della Ricerca | en |
| dc.contributor.funder | European Commission | en |
| dc.date.accessioned | 2020-04-08T08:55:36Z | |
| dc.date.available | 2020-04-08T08:55:36Z | |
| dc.date.issued | 2020-12-24 | |
| dc.date.updated | 2020-04-06T16:48:58Z | |
| dc.description.abstract | Bile acid (BA) signatures are altered in many disease states. BA metabolism is an important microbial function to assist gut colonization and persistence, as well as microbial survival during gastro intestinal (GI) transit and it is an important criteria for potential probiotic bacteria. Microbes that express bile salt hydrolase (BSH), gateway BA modifying enzymes, are considered to have an advantage in the gut. This property is reported as selectively limited to gut-associated microbes. Food-associated microbes have the potential to confer health benefits to the human consumer. Here, we report that food associated Lactobacillus plantarum strains are capable of BA metabolism, they can withstand BA associated stress and propagate, a recognised important characteristic for GIT survival. Furthermore, we report that these food associated Lactobacillus plantarum strains have the selective ability to alter BA signatures in favour of receptor activation that would be beneficial to humans. Indeed, all of the strains examined showed a clear preference to alter human glycol-conjugated BAs, although clear strain-dependent modifications were also evident. This study demonstrates that BA metabolism by food-borne non-pathogenic bacteria is beneficial to both microbe and man and it identifies an evolutionary-conserved characteristic, previously considered unique to gut residents, among food-associated non-pathogenic isolates. | en |
| dc.description.sponsorship | Ministero dell’Istruzione, dell’Università e della Ricerca (Italian Ministry of University and Research (PRIN Project WZ2NJN_005, University of Teramo Unit)); Science Foundation Ireland/ European Commission (SFI-EU JPI CABALA (Grant Number 16/ERA-HDHL/3358)); | en |
| dc.description.status | Peer reviewed | en |
| dc.description.version | Published Version | en |
| dc.format.mimetype | application/pdf | en |
| dc.identifier.articleid | 1165 | en |
| dc.identifier.citation | Prete, R., Long, S.L., Gallardo, A.L., Gahan, C. G., Corsetti, A. and Joyce, S. A. (2020) ‘Beneficial bile acid metabolism from Lactobacillus plantarum of food origin’, Scientific Reports, 10, 1165 (11 pp). doi: 10.1038/s41598-020-58069-5 | en |
| dc.identifier.doi | 10.1038/s41598-020-58069-5 | en |
| dc.identifier.endpage | 11 | en |
| dc.identifier.issn | 2045-2322 | |
| dc.identifier.issued | 1 | en |
| dc.identifier.journaltitle | Scientific Reports | en |
| dc.identifier.startpage | 1 | en |
| dc.identifier.uri | https://hdl.handle.net/10468/9817 | |
| dc.identifier.volume | 10 | en |
| dc.language.iso | en | en |
| dc.publisher | Springer Nature | en |
| dc.relation.project | info:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/ | en |
| dc.relation.uri | https://www.nature.com/articles/s41598-020-58069-5 | |
| dc.rights | © The Author(s) 2020. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. | en |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/. | en |
| dc.subject | Bile acid (BA) signatures | en |
| dc.subject | Microbes | en |
| dc.subject | Gut | en |
| dc.subject | Microbial function | en |
| dc.title | Beneficial bile acid metabolism from Lactobacillus plantarum of food origin | en |
| dc.type | Article (peer-reviewed) | en |
