Heat-killed lactobacilli alter both microbiota composition and behaviour

Simple item page
dc.contributor.authorWarda, Alicja K.
dc.contributor.authorRea, Kieran
dc.contributor.authorFitzgerald, Patrick
dc.contributor.authorHueston, Cara M.
dc.contributor.authorGonzalez-Tortuero, Enrique
dc.contributor.authorDinan, Timothy G.
dc.contributor.authorHill, Colin
dc.contributor.funderAdare Pharmaceuticalen
dc.contributor.funderScience Foundation Irelanden
dc.date.accessioned2019-02-11T12:27:31Z
dc.date.available2019-02-11T12:27:31Z
dc.date.issued2019-04-19
dc.description.abstractRecently it has been proposed to expand the definition of psychobiotics (beneficial bacteria (probiotics) or support for such bacteria (prebiotics) that positively impact mental health) to any exogenous influence whose effect on the brain is bacterially-mediated. This definition would include inactivated microorganisms with anxiolytic and antidepressant effects. The use of inactivated microorganisms has several advantages over living organisms, including no risk of infection in vulnerable individuals and ease of use in terms of storage and delivery options. It has been reported that consumption of inactivated microorganisms can affect behaviour, particularly in chronic or prolonged stress situations, but effects on healthy populations have not been investigated to the same extent. Also, only limited data is available on the effects of inactivated microorganisms on the microbiota of healthy individuals (animal or human). Therefore, we investigated the effect of feeding a standard mouse chow which incorporates ADR-159, a heat-killed fermentate generated by two Lactobacillus strains, on the behaviour and microbiota of healthy mice.Prolonged consumption of ADR-159 diet had no adverse effect on anthropometrics or general health, but the ADR-159 fed animals demonstrated increased sociability and lower baseline corticosterone levels (stress hormone). The diet also led to subtle but significant changes in the microbiota, with less abundant taxa being most affected. The behavioural, biochemical and microbiological results provide a new light on the impact of inactivated microorganisms and their metabolites on the social behaviour and microbiota of healthy mice.en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationWarda, A. K., Rea, K., Fitzgerald, P., Hueston, C., Gonzalez-Tortuero, E., Dinan, T. G. and Hill, C. (2019) 'Heat-killed lactobacilli alter both microbiota composition and behaviour', Behavioural Brain Research, 362, pp. 213-223. DOI: 10.1016/j.bbr.2018.12.047en
dc.identifier.doi10.1016/j.bbr.2018.12.047
dc.identifier.endpage223en
dc.identifier.issn0166-4328
dc.identifier.journaltitleBehavioural Brain Researchen
dc.identifier.startpage213en
dc.identifier.urihttps://hdl.handle.net/10468/7475
dc.identifier.volume362en
dc.language.isoenen
dc.publisherElsevieren
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/en
dc.relation.urihttp://www.sciencedirect.com/science/article/pii/S016643281830994X
dc.rights© 2019 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/)en
dc.rights.urihttp://creativecommons.org/licenses/BY-NC-ND/4.0/en
dc.subjectGut-brain axisen
dc.subjectBehaviouren
dc.subjectSocial preferenceen
dc.subjectHeat-inactivated bacteriaen
dc.subjectLactobacillusen
dc.subjectParaprobioticsen
dc.titleHeat-killed lactobacilli alter both microbiota composition and behaviouren
dc.typeArticle (peer-reviewed)en
Files
Original bundle
Now showing 1 - 2 of 2
Thumbnail Image
Name:
1-s2.0-S016643281830994X-main.pdf
Size:
2.36 MB
Format:
Adobe Portable Document Format
Description:
Published Version
Download
Thumbnail Image
Name:
1-s2.0-S016643281830994X-mmc1.doc
Size:
489.5 KB
Format:
Microsoft Word
Description:
Supplementary Data
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
2.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Microbiology - Journal Articles
APC Microbiome Ireland - Journal Articles
Psychiatry - Journal Articles