Adverse pregnancy outcomes and long-term risk of maternal renal disease: a systematic review and meta-analysis protocol

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dc.contributor.authorBarrett, Peter M.
dc.contributor.authorMcCarthy, Fergus P.
dc.contributor.authorKublickiene, Karolina
dc.contributor.authorEvans, Marie
dc.contributor.authorCormican, Sarah
dc.contributor.authorJudge, Conor
dc.contributor.authorPerry, Ivan J.
dc.contributor.authorKublickas, Marius
dc.contributor.authorStenvinkel, Peter
dc.contributor.authorKhashan, Ali S.
dc.contributor.funderHealth Research Boarden
dc.contributor.funderWellcome Trusten
dc.contributor.funderHealth Service Executiveen
dc.contributor.funderHealth and Social Care, Research and Development, Northern Irelanden
dc.date.accessioned2019-11-20T05:21:54Z
dc.date.available2019-11-20T05:21:54Z
dc.date.issued2019-05-05
dc.description.abstractIntroduction: Adverse pregnancy outcomes, such as hypertensive disorders of pregnancy (HDP), gestational diabetes (GDM) and preterm birth have been linked to maternal cardiovascular disease in later life. Pre-eclampsia (PE) is associated with an increased risk of postpartum microalbuminuria, but there is no clear consensus on whether HDP increases the risk of maternal chronic kidney disease (CKD) and end-stage kidney disease (ESKD). Similarly, it is uncertain whether GDM, preterm birth and delivery of low birth-weight infants independently predict the risk of maternal renal disease in later life. The aims of this proposed systematic review and meta-analysis are to summarise the available evidence examining the association between adverse outcomes of pregnancy (HDP, GDM, preterm birth, delivery of low birth-weight infant) and later maternal renal disease and to synthesise the results of relevant studies. Methods and analysis: A systematic search of PubMed, EMBASE and Web of Science will be undertaken using a detailed prespecified search strategy. Two authors will independently review the titles and abstracts of all studies, perform data extraction and appraise the quality of included studies using a bias classification tool. Original case–control and cohort studies published in English will be considered for inclusion. Primary outcomes of interest will be CKD and ESKD; secondary outcomes will be hospitalisation for renal disease and deaths from renal disease. Meta-analyses will be performed to calculate the overall pooled estimates using the generic inverse variance method. The systematic review will follow the Meta-analyses Of Observational Studies in Epidemiology guidelines. Ethics and dissemination: This systematic review and meta-analysis will be based on published data, and thus there is no requirement for ethics approval. The results will be shared through publication in a peer reviewed journal and through presentations at academic conferences. PROSPERO registration number CRD42018110891en
dc.description.sponsorship203930/B/16/Zen
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleide027180en
dc.identifier.citationBarrett, P.M., McCarthy, F.P., Kublickiene, K., Evans, M., Cormican, S., Judge, C., Perry, I.J., Kublickas, M., Stenvinkel, P. and Khashan, A.S., 2019. Adverse pregnancy outcomes and long-term risk of maternal renal disease: a systematic review and meta-analysis protocol. BMJ open, 9(5), (e027180). DOI:10.1136/bmjopen-2018-027180en
dc.identifier.doi10.1136/bmjopen-2018-027180en
dc.identifier.eissn2044-6055
dc.identifier.endpage5en
dc.identifier.issued5en
dc.identifier.journaltitleBMJ Openen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/9117
dc.identifier.volume9en
dc.language.isoenen
dc.publisherBMJ Publishing Groupen
dc.relation.urihttps://bmjopen.bmj.com/content/9/5/e027180
dc.rights© Author(s) (or their employer(s)) 2019. Published by BMJen
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectAdverse preganancy outcomesen
dc.subjectMaternal renal diseaseen
dc.subjectPregnancyen
dc.titleAdverse pregnancy outcomes and long-term risk of maternal renal disease: a systematic review and meta-analysis protocolen
dc.typeArticle (peer-reviewed)en
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