Swallow-breathing coordination during incremental ascent to altitude

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dc.contributor.authorHuff, Alyssa
dc.contributor.authorDay, Trevor A.
dc.contributor.authorEnglish, Mason
dc.contributor.authorReed, Mitchell D.
dc.contributor.authorZouboules, Shaelynn
dc.contributor.authorSaran, Gurkarn
dc.contributor.authorLeacy, Jack K.
dc.contributor.authorMann, Carli
dc.contributor.authorPeltonen, Joel D. B.
dc.contributor.authorO'Halloran, Ken D.
dc.contributor.authorSherpa, Mingma T.
dc.contributor.authorPitts, Teresa
dc.contributor.funderNational Institutes of Health
dc.contributor.funderKentucky Spinal Cord and Head Injury Trust
dc.contributor.funderUniversity of Louisville
dc.contributor.funderNatural Sciences and Engineering Research Council of Canada
dc.date.accessioned2024-02-28T16:06:21Z
dc.date.available2024-02-28T16:06:21Z
dc.date.issued2019
dc.description.abstractSwallow and breathing are highly coordinated behaviors reliant on shared anatomical space and neural pathways. Incremental ascent to high altitudes results in hypoxia/hypocapnic conditions altering respiratory drive, however it is not known whether these changes also alter swallow. We examined the effect of incremental ascent (1045 m, 3440 m and 4371 m) on swallow motor pattern and swallow-breathing coordination in seven healthy adults. Submental surface electromyograms (sEMG) and spirometry were used to evaluate swallow triggered by saliva and water infusion. Swallow-breathing phase preference was different between swallows initiated by saliva versus water. With ascent, saliva swallows changed to a dominate pattern of occurrence during the transition from inspiration to expiration. Additionally, water swallows demonstrated a significant decrease in submental sEMG duration and a shift in submental activity to earlier in the apnea period, especially at 4371 m. Our results suggest that there are changes in swallow-breathing coordination and swallow production that likely increase airway protection with incremental ascent to high altitude. The adaptive changes in swallow were likely due to the exposure to hypoxia and hypocapnia, along with airway irritation. © 2018 Elsevier B.V.en
dc.description.sponsorshipNational Institutes of Health (R00-HL 111215 ); University of Louisville (The Commonwealth of Kentucky Challenge for Excellence);Natural Sciences and Engineering Research Council of Canada (Discovery grant RGPIN-2016-04915 )en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationHuff, A., Day, T. A., English, M., Reed, M. D., Zouboules, S., Saran, G., Leacy, J. K., Mann, C., Peltonen, J. D., O’Halloran, K. D. and Sherpa, M. T. (2019) 'Swallow-breathing coordination during incremental ascent to altitude', Respiratory Physiology and Neurobiology, 265, pp.121-126. https://doi.org/10.1016/j.resp.2018.06.005en
dc.identifier.doihttps://doi.org/10.1016/j.resp.2018.06.005
dc.identifier.endpage126
dc.identifier.issn15699048
dc.identifier.journaltitleRespiratory Physiology and Neurobiologyen
dc.identifier.startpage121
dc.identifier.urihttps://hdl.handle.net/10468/15597
dc.identifier.volume265
dc.language.isoenen
dc.publisherElsevier B.V.en
dc.rights© 2019, Elsevier Ltd. All rights reserved. This manuscript version is made available under the CC BY-NC-ND 4.0 license.en
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectAirflowen
dc.subjectAirway protectionen
dc.subjectApnea durationen
dc.subjectElectromyogramsen
dc.subjectHigh altitude ascenten
dc.subjectSwallow coordinationen
dc.titleSwallow-breathing coordination during incremental ascent to altitudeen
dc.typeArticle (peer-reviewed)en
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