Structure-activity relationships of furanones, dihydropyrrolones and thiophenones as potential quorum sensing inhibitors

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dc.contributor.authorLyons, Thérèse
dc.contributor.authorGahan, Cormac G. M.
dc.contributor.authorO'Sullivan, Timothy P.
dc.contributor.funderScience Foundation Irelanden
dc.contributor.funderUniversity College Corken
dc.contributor.funderFuture University in Egypten
dc.date.accessioned2020-12-07T09:47:54Z
dc.date.available2020-12-07T09:47:54Z
dc.date.issued2020-10-23
dc.date.updated2020-12-07T09:26:35Z
dc.description.abstractSince their initial isolation from the marine alga Delisea pulchra, bromofuranones have been investigated as potential inhibitors of quorum sensing (QS) in various bacterial strains. QS is an important mechanism by which bacteria co-ordinate their molecular response to the environment. QS is intrinsically linked to bacterial antibiotic resistance. Inspired by nature, chemists have developed a wide variety of synthetic analogs in an effort to elucidate the structure-activity relationships of these compounds, and to ultimately develop novel antimicrobial agents. In this work, we describe advances in this field while paying particular attention to apparent structure-activity relationships. This review is organized according to the main ring systems under investigation, namely furanones, dihydropyrrolones and thiophenones.en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationLyons, T., Gahan, C. G. M. and O'Sullivan, T. P. (2020) 'Structure-activity relationships of furanones, dihydropyrrolones and thiophenones as potential quorum sensing inhibitors', Future Medicinal Chemistry, 12(21), pp. 1925-1943. doi: 10.4155/fmc-2020-0244en
dc.identifier.doi10.4155/fmc-2020-0244en
dc.identifier.eissn1756-8927
dc.identifier.endpage1943en
dc.identifier.issn1756-8919
dc.identifier.issued21en
dc.identifier.journaltitleFuture Medicinal Chemistryen
dc.identifier.startpage1925en
dc.identifier.urihttps://hdl.handle.net/10468/10820
dc.identifier.volume12en
dc.language.isoenen
dc.publisherNewlands Pressen
dc.relation.projectScience Foundation Ireland (SFI/12/RC/2273_P2)en
dc.rights© 2020, Newlands Press. All rights reserved.en
dc.subjectDihydropyrrolonesen
dc.subjectFuranonesen
dc.subjectQuorum sensingen
dc.subjectResistanceen
dc.subjectThiophenonesen
dc.titleStructure-activity relationships of furanones, dihydropyrrolones and thiophenones as potential quorum sensing inhibitorsen
dc.typeArticle (peer-reviewed)en
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