Continuous powder feeding: Equipment design and material considerations

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dc.check.date2023-04-07
dc.check.infoAccess to this item is restricted until 12 months after publication by request of the publisher.en
dc.contributor.authorKerins, Brian M.
dc.contributor.authorCrean, Abina M.
dc.contributor.funderScience Foundation Ireland
dc.date.accessioned2022-04-27T14:05:08Z
dc.date.available2022-04-27T14:05:08Z
dc.date.issued2022-04-07
dc.date.updated2022-04-27T13:52:39Z
dc.description.abstractThe continuous feeding of raw materials is a fundamental initial step in the continuous production of solid dosage forms. The continuous feeding process is considered critical as deviations or disturbances in individual feeders may produce compositional variability in the following mixing steps. This variability may then impact downstream unit operations and result in a detrimental change to the quality attributes of the final product. To design a robust feeding process and optimise the feeding performance, it is essential to understand feeder design and the underlying relationships between the material properties, feeder tooling configuration and feeding process parameters. In this chapter a brief overview of continuous feeding equipment and feeder operation modes is provided. The chapter describes the equipment and process considerations for the design of a continuous feeding process, with a primary focus on loss-in-weight (LIW), twin-screw feeders, primarily employed during the continuous production of pharmaceutical solid dosage forms. The chapter finishes with a description of modelling approaches employed to investigate feeder performance and the integration of the feeding process to the subsequent steps of the overall continuous manufacturing process.en
dc.description.sponsorshipScience Foundation Ireland (12/RC/2275-P2)en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationKerins, B. M. and Crean, A. M. (2022) 'Continuous powder feeding: Equipment design and material considerations', in Fytopoulos, A., Ramachandran, R. and Pardalos, P. M. (eds) Optimization of Pharmaceutical Processes. Springer Optimization and Its Applications, 189, pp. 171–191. Springer, Cham. doi: 10.1007/978-3-030-90924-6_7en
dc.identifier.doi10.1007/978-3-030-90924-6_7en
dc.identifier.eissn1931-6836
dc.identifier.endpage191en
dc.identifier.issn1931-6828
dc.identifier.journaltitleSpringer Optimization and Its Applicationsen
dc.identifier.startpage171en
dc.identifier.urihttps://hdl.handle.net/10468/13123
dc.identifier.volume189en
dc.language.isoenen
dc.publisherSpringer Nature Switzerland AGen
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2275/IE/Synthesis and Solid State Pharmaceutical Centre (SSPC)/
dc.rights© 2022, the Authors, under exclusive license to Springer Nature Switzerland AG. The final authenticated version is available online at: https://doi.org/10.1007/978-3-030-90924-6_7en
dc.subjectContinuous feedingen
dc.subjectSolid dosageen
dc.subjectEquipmenten
dc.subjectFeeder operation modesen
dc.subjectLoss-in-weight (LIW)en
dc.subjectTwin Screw feedersen
dc.subjectGravimetric powder feedingen
dc.subjectHopper refillen
dc.titleContinuous powder feeding: Equipment design and material considerationsen
dc.typeBook chapteren
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