Age-associated deficits in social behaviour are microbiota-dependent

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dc.contributor.authorCruz-Pereira, Joana S.en
dc.contributor.authorMoloney, Gerard M.en
dc.contributor.authorBastiaanssen, Thomaz F. S.en
dc.contributor.authorBoscaini, Serenaen
dc.contributor.authorFitzgerald, Patricken
dc.contributor.authorClarke, Gerarden
dc.contributor.authorCryan, John F.en
dc.contributor.funderScience Foundation Irelanden
dc.contributor.funderSaks-Kavanaugh Foundationen
dc.contributor.funderSchweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschungen
dc.date.accessioned2023-03-31T08:56:48Z
dc.date.available2023-03-31T08:56:48Z
dc.date.issued2023en
dc.description.abstractAging is associated with remodelling of immune and central nervous system responses resulting in behavioural impairments including social deficits. Growing evidence suggests that the gut microbiome is also impacted by aging, and we propose that strategies to reshape the aged gut microbiome may ameliorate some age-related effects on host physiology. Thus, we assessed the impact of gut microbiota depletion, using an antibiotic cocktail, on aging and its impact on social behavior and the immune system. Indeed, microbiota depletion in aged mice eliminated the age-dependent deficits in social recognition. We further demonstrate that although age and gut microbiota depletion differently shape the peripheral immune response, aging induces an accumulation of T cells in the choroid plexus, that is partially blunted following microbiota depletion. Moreover, an untargeted metabolomic analysis revealed age-dependent alterations of cecal metabolites that are reshaped by gut microbiota depletion. Together, our results suggest that the aged gut microbiota can be specifically targeted to affect social deficits. These studies propel the need for future investigations of other non-antibiotic microbiota targeted interventions on age-related social deficits both in animal models and humans.
dc.description.sponsorshipSaks Kavanaugh Foundation and Swiss National Science Foundation (Project CRSII5_186,346/NMS 2068)en
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationCruz-Pereira, J.S., Moloney, G.M., Bastiaanssen, T.F.S., Boscaini, S., Fitzgerald, P., Clarke, G. and Cryan, J.F. (2023) ‘Age-associated deficits in social behaviour are microbiota-dependent’, Brain, Behavior, and Immunity, 110, pp. 119–124. doi: 10.1016/j.bbi.2023.02.008en
dc.identifier.doi10.1016/j.bbi.2023.02.008en
dc.identifier.endpage124en
dc.identifier.issn0889-1591en
dc.identifier.journaltitleBrain, Behavior, and Immunityen
dc.identifier.startpage119en
dc.identifier.urihttps://hdl.handle.net/10468/14341
dc.identifier.volume110en
dc.language.isoenen
dc.publisherElsevieren
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres Programme::Phase 2/12/RC/2273_P2/IE/APC_Phase 2/en
dc.rights© 2023 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectAgingen
dc.subjectMicrobiomeen
dc.subjectSocial behaviouren
dc.subjectMetabolitesen
dc.titleAge-associated deficits in social behaviour are microbiota-dependenten
dc.typeArticle (peer-reviewed)en
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