Of bowels, brain and behavior: A role for the gut microbiota in psychiatric comorbidities in irritable bowel syndrome

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dc.contributor.authorWilmes, Lars
dc.contributor.authorCollins, James M.
dc.contributor.authorO'Riordan, Kenneth J.
dc.contributor.authorO'Mahony, Siobhain M.
dc.contributor.authorCryan, John F.
dc.contributor.authorClarke, Gerard
dc.contributor.funderScience Foundation Irelanden
dc.contributor.funderHorizon 2020en
dc.date.accessioned2021-03-29T10:44:36Z
dc.date.available2021-03-29T10:44:36Z
dc.date.issued2021-02-13
dc.date.updated2021-03-05T11:14:07Z
dc.description.abstractBackground: The gastrointestinal microbiota has emerged as a key regulator of gut-brain axis signalling with important implications for neurogastroenterology. There is continuous bidirectional communication between the gut and the brain facilitated by neuronal, endocrine, metabolic, and immune pathways. The microbiota influences these signalling pathways via several mechanisms. Studies have shown compositional and functional alterations in the gut microbiota in stress-related psychiatric disorders. Gut microbiota reconfigurations are also a feature of irritable bowel syndrome (IBS), a gut-brain axis disorder sharing high levels of psychiatric comorbidity including both anxiety and depression. It remains unclear how the gut microbiota alterations in IBS align with both core symptoms and these psychiatric comorbidities. Methods: In this review, we highlight common and disparate features of these microbial signatures as well as the associated gut-brain axis signalling pathways. Studies suggest that patients with either IBS, depression or anxiety, alone or comorbid, present with alterations in gut microbiota composition and harbor immune, endocrine, and serotonergic system alterations relevant to the common pathophysiology of these comorbid conditions. Key results: Research has illustrated the utility of fecal microbiota transplantation in animal models, expanding the evidence base for a potential causal role of disorder-specific gut microbiota compositions in symptom set expression. Moreover, an exciting study by Constante and colleagues in this issue highlights the possibility of counteracting this microbiota-associated aberrant behavioral phenotype with a probiotic yeast, Saccharomyces boulardii CNCM I-745. Conclusions and inferences: Such data highlights the potential for therapeutic targeting of the gut microbiota as a valuable strategy for the management of comorbid psychiatric symptoms in IBS.en
dc.description.sponsorshipScience Foundation Ireland (SFI/12/RC/2273_P2)en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleide14095en
dc.identifier.citationWilmes, L., Collins, J. M., O'Riordan, K. J., O'Mahony, S. M., Cryan, J. F. and Clarke, G. (2021) 'Of bowels, brain and behavior: A role for the gut microbiota in psychiatric comorbidities in irritable bowel syndrome', Neurogastroenterology and Motility, 33(3), e14095 (13pp). doi: 10.1111/nmo.14095en
dc.identifier.doi10.1111/nmo.14095en
dc.identifier.eissn1365-2982
dc.identifier.endpage13en
dc.identifier.issn1350-1925
dc.identifier.issued3en
dc.identifier.journaltitleNeurogastroenterology and Motilityen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/11166
dc.identifier.volume33en
dc.language.isoenen
dc.publisherJohn Wiley & Sons, Inc.en
dc.relation.projectinfo:eu-repo/grantAgreement/EC/H2020::RIA/848228/EU/Development, dIagnostic and prevention of gender-related Somatic and mental COmorbitiEs in iRritable bowel syndrome In Europe/DISCOvERIEen
dc.rights© 2021, John Wiley & Sons, Inc. This is the peer reviewed version of the following item: Wilmes, L., Collins, J. M., O'Riordan, K. J., O'Mahony, S. M., Cryan, J. F. and Clarke, G. (2021) 'Of bowels, brain and behavior: A role for the gut microbiota in psychiatric comorbidities in irritable bowel syndrome', Neurogastroenterology and Motility, 33(3), e14095 (13pp), doi: 10.1111/nmo.14095, which has been published in final form at https://doi.org/10.1111/nmo.14095. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.en
dc.subjectAnxietyen
dc.subjectComorbidityen
dc.subjectDepressionen
dc.subjectIBSen
dc.subjectMicrobiota-gut-brain axisen
dc.titleOf bowels, brain and behavior: A role for the gut microbiota in psychiatric comorbidities in irritable bowel syndromeen
dc.typeArticle (peer-reviewed)en
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